Novel in silico tools for designing peptide-based subunit vaccines and immunotherapeutics

SK Dhanda, SS Usmani, P Agrawal… - Briefings in …, 2017 - academic.oup.com
The conventional approach for designing vaccine against a particular disease involves
stimulation of the immune system using the whole pathogen responsible for the disease. In …

Key Limitations and New Insights Into the Toxoplasma gondii Parasite Stage Switching for Future Vaccine Development in Human, Livestock, and Cats

MN Mévélec, Z Lakhrif, I Dimier-Poisson - Frontiers in cellular and …, 2020 - frontiersin.org
Toxoplasmosis is a parasitic disease affecting human, livestock and cat. Prophylactic
strategies would be ideal to prevent infection. In a One Health vaccination approach, the …

Toxoplasma gondii peptide ligands open the gate of the HLA class I binding groove

C McMurtrey, T Trolle, T Sansom, SG Remesh… - Elife, 2016 - elifesciences.org
HLA class I presentation of pathogen-derived peptide ligands is essential for CD8+ T-cell
recognition of Toxoplasma gondii infected cells. Currently, little data exist pertaining to …

[HTML][HTML] An overview of peripheral blood mononuclear cells as a model for immunological research of Toxoplasma gondii and other apicomplexan parasites

JAA Davila, AH De Los Rios - Frontiers in cellular and infection …, 2019 - ncbi.nlm.nih.gov
In biology, models are experimental systems meant to recreate aspects of diseases or
human tissue with the goal of generating inferences and approximations that can contribute …

An Overview of Peripheral Blood Mononuclear Cells as a Model for Immunological Research of Toxoplasma gondii and Other Apicomplexan Parasites

JA Acosta Davila… - Frontiers in cellular and …, 2019 - frontiersin.org
In biology, models are experimental systems meant to recreate aspects of diseases or
human tissue with the goal of generating inferences and approximations that can contribute …

Immunization with the amino-terminus region of dense granule protein 6 (GRA6) of Toxoplasma gondii activates CD8+ cytotoxic T cells capable of removing tissue …

R Mani, C Mercier, MF Delauw, Y Suzuki - Microbes and Infection, 2023 - Elsevier
Abstract CD8+ T cells from HLA-A2. 1-transgenic mice, but not wild-type mice, immunized
with the amino-terminus region (aa 41–152) of dense granule protein 6 (GRA6Nt) of …

In silico identification and ex vivo evaluation of Toxoplasma gondii peptides restricted to HLA-A*02, HLA-A*24 and HLA-B*35 alleles in human PBMC from a …

M Vargas-Montes, MC Valencia-Jaramillo… - Medical Microbiology …, 2025 - Springer
Toxoplasma gondii infects approximately 30% of the population, and there is currently no
approved vaccine. Identifying immunogenic peptides with high affinity to different HLA …

Ocular toxoplasmosis: susceptibility in respect to the genes encoding the KIR receptors and their HLA class I ligands

CM Ayo, FB Frederico, RC Siqueira… - Scientific reports, 2016 - nature.com
The objective of this study was to investigate the influence of the genes encoding the KIR
receptors and their HLA ligands in the susceptibility of ocular toxoplasmosis. A total of 297 …

Human MHC class I molecule, HLA-A2. 1, mediates activation of CD8+ T cell IFN-γ production and the T cell-dependent protection against reactivation of cerebral …

R Mani, MH Abdelaziz, A Michelon… - Frontiers in …, 2022 - frontiersin.org
To examine whether the HLA-A2. 1, one of the most common MHC class I molecules in
humans, activates the protective immunity against reactivation of cerebral infection with …

[HTML][HTML] Toxoplasma gondii, Brazil

J Gomez-Marin - Emerging Infectious Diseases, 2007 - ncbi.nlm.nih.gov
To the Editor: Recently, Jones et al. reported that past pregnancies increased risk for recent
Toxoplasma gondii infection in Brazil (1). They did not, however, control for age. Previous …