Much of the mortality attributed to influenza virus is due to secondary bacterial pneumonia,
particularly from Streptococcus pneumoniae. However, mechanisms underlying this …

Lactococcus lactis is of great importance for the nutrition of hundreds of millions of people
worldwide. This paper describes the genome sequence of Lactococcus lactis subsp …

While some bacteria can thrive for generations in minerals and salts, many require lavish
nutrition and specific chemicals to survive to the point where they can be observed and …

We describe the development of genetic tools for regulated gene expression, the
introduction of chromosomal mutations, and improved plasmid transfer by electroporation in …

High levels of copper are toxic and therefore bacteria must limit free intracellular levels to
prevent cellular damage. In this study, we show that a number of pneumococcal genes are …

In Gram-positive bacteria, the transcriptional regulator CcpA is at the core of catabolite
control mechanisms. In the human pathogen Streptococcus pneumoniae, links between …

Several genes involved in nitrogen metabolism are known to contribute to the virulence of
pathogenic bacteria. Here, we studied the function of the nitrogen regulatory protein GlnR in …

Maintenance of the intracellular homeostasis of metal ions is important for the virulence of
many bacterial pathogens. Here, we demonstrate that the czcD gene of the human pathogen …

The human pathogen Streptococcus pneumoniae is a strictly fermentative organism that
relies on glycolytic metabolism to obtain energy. In the human nasopharynx S. pneumoniae …

Streptococcus pneumoniae (pneumococcus) is a major bacterial pathogen that causes
pneumonia and septicemia in humans. Pneumococci are cleared from the host primarily by …