Data science approaches to infectious disease surveillance

Q Zhang - … Transactions of the Royal Society A, 2022 - royalsocietypublishing.org
Novel data science approaches are needed to confront large-scale infectious disease
epidemics such as COVID-19, human immunodeficiency viruses, African swine flu and …

Controlling epidemics through optimal allocation of test kits and vaccine doses across networks

M Xia, L Böttcher, T Chou - IEEE Transactions on Network …, 2022 - ieeexplore.ieee.org
Efficient testing and vaccination protocols are critical aspects of epidemic management. To
study the optimal allocation of limited testing and vaccination resources in a heterogeneous …

Bayesian sequential approach to monitor COVID-19 variants through test positivity rate from wastewater

JC Montesinos-López, ML Daza-Torres, YE García… - Msystems, 2023 - Am Soc Microbiol
Deployment of clinical testing on a massive scale was an essential control measure for
curtailing the burden of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Prevalence estimation and optimal classification methods to account for time dependence in antibody levels

P Bedekar, AJ Kearsley, PN Patrone - Journal of Theoretical Biology, 2023 - Elsevier
Serology testing can identify past infection by quantifying the immune response of an
infected individual providing important public health guidance. Individual immune responses …

Modeling in higher dimensions to improve diagnostic testing accuracy: theory and examples for multiplex saliva-based SARS-CoV-2 antibody assays

RA Luke, AJ Kearsley, N Pisanic, YC Manabe… - PloS one, 2023 - journals.plos.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
emphasized the importance and challenges of correctly interpreting antibody test results …

Optimal classification and generalized prevalence estimates for diagnostic settings with more than two classes

RA Luke, AJ Kearsley, PN Patrone - Mathematical Biosciences, 2023 - Elsevier
An accurate multiclass classification strategy is crucial to interpreting antibody tests.
However, traditional methods based on confidence intervals or receiver operating …

Optimal decision theory for diagnostic testing: Minimizing indeterminate classes with applications to saliva-based SARS-CoV-2 antibody assays

PN Patrone, P Bedekar, N Pisanic, YC Manabe… - Mathematical …, 2022 - Elsevier
In diagnostic testing, establishing an indeterminate class is an effective way to identify
samples that cannot be accurately classified. However, such approaches also make testing …

Operational analysis for COVID-19 testing: Determining the risk from asymptomatic infections

M Mangel - Plos one, 2023 - journals.plos.org
Testing remains a key tool for managing health care and making health policy during the
coronavirus pandemic, and it will probably be important in future pandemics. Because of …

Minimizing uncertainty in prevalence estimates

PN Patrone, AJ Kearsley - Statistics & Probability Letters, 2024 - Elsevier
Estimating prevalence q, the fraction of a population with a specific medical condition, is
fundamental to epidemiology. Traditional methods address this task by using a diagnostic …

[HTML][HTML] Bayesian sequential approach to monitor covid-19 variants through positivity rate from wastewater

JC Montesinos-López, ML Daza–Torres, YE García… - medRxiv, 2023 - ncbi.nlm.nih.gov
Trends in COVID-19 infection have changed throughout the pandemic due to myriad factors,
including changes in transmission driven by social behavior, vaccine development and …