Hemorrhagic fevers (HF) resulting from pathogenic arenaviral infections have traditionally
been neglected as tropical diseases primarily affecting African and South American regions …

The arenavirus genome comprises two single-stranded RNA molecules of negative polarity,
designated L and S, that contain essentially nonoverlapping sequence information (for …

The arenavirus Lassa virus causes Lassa fever, a viral hemorrhagic fever that is endemic in
the countries of Nigeria, Sierra Leone, Liberia, and Guinea and perhaps elsewhere in West …

Viruses of theArenaviridaecause hemorrhagic fevers and neurologic disease in humans.
Historically, the arenaviruses have been divided into two complexes (LASV-LCMV …

The envelope glycoprotein (GP) of lymphocytic choriomeningitis virus (LCMV) is
posttranslationally cleaved into two subunits. We show here that this endoproteolytic …

Arenaviruses comprise a diverse family of rodent-borne viruses that are responsible for
recurring and emerging outbreaks of viral hemorrhagic fevers worldwide. The Junín virus, a …

The envelope glycoprotein of the arenaviruses (GP-C) is unusual in that the mature complex
retains the cleaved, 58-amino-acid signal peptide. Association of this stable signal peptide …

Arenaviruses are responsible for acute hemorrhagic fevers with high mortality and pose
significant threats to public health and biodefense. These enveloped negative-sense RNA …

The arenavirus envelope glycoprotein (GPC) mediates viral entry through pH-induced
membrane fusion in the endosome. This crucial process in the viral life cycle can be …

Argentine hemorrhagic fever (AHF) is an endemo-epidemic disease caused by Junín virus
(JUNV), a member of the arenaviridae family. Although a recently introduced live attenuated …