Application of a deep-learning marker for morbidity and mortality prediction derived from retinal photographs: a cohort development and validation study

S Nusinovici, TH Rim, H Li, M Yu… - The Lancet Healthy …, 2024 - thelancet.com
Background Biological ageing markers are useful to risk stratify morbidity and mortality more
precisely than chronological age. In this study, we aimed to develop a novel deep-learning …

Glycemic status and its association with retinal age gap: Insights from the UK biobank study

R Chen, J Xu, X Zhang, J Zhang, X Shang, Z Ge… - Diabetes Research and …, 2023 - Elsevier
Objective To investigate associations between different glycemic status and biological age
indexed by retinal age gap. Methods A total of 28,919 participants from the UK Biobank …

Machine learning derived retinal pigment score from ophthalmic imaging shows ethnicity is not biology

AE Rajesh, A Olvera-Barrios, AN Warwick, Y Wu… - Nature …, 2025 - nature.com
Few metrics exist to describe phenotypic diversity within ophthalmic imaging datasets, with
researchers often using ethnicity as a surrogate marker for biological variability. We derived …

Rbad: A dataset and benchmark for retinal vessels branching angle detection

H Wang, W Zhu, J Qin, X Li, O Dumitrascu… - arXiv preprint arXiv …, 2024 - arxiv.org
Detecting retinal image analysis, particularly the geometrical features of branching points,
plays an essential role in diagnosing eye diseases. However, existing methods used for this …

Deep ocular phenotyping across primary open-angle glaucoma genetic burden

S Sekimitsu, D Xiang, SL Smith, K Curran… - JAMA …, 2023 - jamanetwork.com
Importance Better understanding of primary open-angle glaucoma (POAG) genetics could
enable timely screening and promote individualized disease risk prognostication. Objective …

[HTML][HTML] Metadata information and fundus image fusion neural network for hyperuricemia classification in diabetes

J Wei, Y Xu, H Wang, T Niu, Y Jiang, Y Shen… - Computer Methods and …, 2024 - Elsevier
Objective In diabetes mellitus patients, hyperuricemia may lead to the development of
diabetic complications, including macrovascular and microvascular dysfunction. However …

Retinal morphology across the menstrual cycle: insights from the UK Biobank

AP Ribeiro Reis, E Ioannidou, SK Wagner… - npj Women's …, 2024 - nature.com
Oestradiol and progesterone levels are higher in menstruating women than men of the same
age, and their receptors are present in their neurosensory retina and retinal pigment …

Differential Organ Ageing Is Associated With Age‐Related Macular Degeneration

A Papadam, A Lionikas, F Grassmann - Aging Cell, 2025 - Wiley Online Library
Age‐related macular degeneration (AMD) is a progressive disorder and the leading cause
of central vision loss. Age is the most important risk factor, followed by genetics and …

Polyunsaturated Fatty Acid-mediated Cellular Rejuvenation for Reversing Age-related Vision Decline

F Gao, E Tom, C Rydz, W Cho, AV Kolesnikov, Y Sha… - …, 2024 - pmc.ncbi.nlm.nih.gov
The retina is uniquely enriched in polyunsaturated fatty acids (PUFAs), which are primarily
localized in cell membranes, where they govern membrane biophysical properties such as …

Associations of Metabolically Healthy Obesity and Retinal Age Gap

X Zeng, R Chen, G Bulloch, Q Peng… - … Vision Science & …, 2024 - tvst.arvojournals.org
Purpose: We investigated the association between metabolically healthy obesity (MHO) and
retinal age gap and explored potential sex differences in this association. Methods: This …