Hypoxia causes the expression of signaling molecules which regulate cell division, lead to
angiogenesis, and further, in the tumor microenvironment, promote resistance to …

Photoacoustic imaging (PAI) is a powerful imaging modality that relies on the PA effect. PAI
works on the principle of electromagnetic energy absorption by the exogenous contrast …

Accurate assessment of the size and depth of infiltration is critical for effectively treating and
removing skin cancer, especially melanoma. However, existing methods such as skin biopsy …

We have developed and optimized an imaging system to study and improve the detection of
brain hemorrhage and to quantify oxygenation. Since this system is intended to be used for …

Significance Photoacoustic imaging (PAI) enables the visualization of optical contrast with
ultrasonic imaging. It is a field of intense research, with great promise for clinical application …

Significance Cutaneous melanoma (CM) has a high morbidity and mortality rate, but it can
be cured if the primary lesion is detected and treated at an early stage. Imaging techniques …

Melanoma is the deadliest form of skin cancer and remains a diagnostic challenge in the
dermatology clinic. Several non-invasive imaging techniques have been developed to …

In vivo fluorescence imaging in the shortwave infrared (SWIR, 1,000–1,700 nm) and
extended SWIR (ESWIR, 1,700–2,700 nm) regions has tremendous potential for diagnostic …

Proximal spinal muscular atrophy (SMA) is a rare progressive, life limiting genetic motor
neuron disease. While promising causal therapies are available, meaningful prognostic …

Skull bone represents a highly acoustical impedance mismatch and a dispersive barrier for
the propagation of acoustic waves. Skull distorts the amplitude and phase information of the …