Repetitive elements in the human genome, once considered 'junk DNA', are now known to
adopt more than a dozen alternative (that is, non-B) DNA structures, such as self-annealed …

In addition to the canonical right-handed double helix, other DNA structures, termed 'non-B
DNA', can form in the genomes across the tree of life. Non-B DNA regulates multiple cellular …

Around 3% of the genome consists of simple DNA repeats that are prone to forming
alternative (non-B) DNA structures, such as hairpins, cruciforms, triplexes (H-DNA), four …

ATRX is a tumor suppressor that has been associated with protection from DNA replication
stress, purportedly through resolution of difficult-to-replicate G-quadruplex (G4) DNA …

Background Many short-read genome assemblies have been found to be incomplete and
contain mis-assemblies. The Vertebrate Genomes Project has been producing new …

DNA becomes single stranded (ssDNA) during replication, transcription, and repair.
Transiently formed ssDNA segments can adopt alternative conformations, including …

Alternative DNA conformations, termed non-B DNA structures, can affect transcription, but
the underlying mechanisms and their functional impact have not been systematically …

The role of alternate DNA conformations such as Z-DNA in the regulation of transcription is
currently underappreciated. These structures are encoded by sequences called flipons …

During replication, folding of the DNA template into non-B-form secondary structures
provides one of the most abundant impediments to the smooth progression of the replisome …

Alternative splicing is central to metazoan gene regulation, but the regulatory mechanisms
are incompletely understood. Here, we show that G-quadruplex (G4) motifs are enriched~ 3 …