Neutrophils in cancer: prognostic role and therapeutic strategies

A Ocana, C Nieto-Jiménez, A Pandiella, AJ Templeton - Molecular cancer, 2017 - Springer
Expression of high levels of immune cells including neutrophils has been associated with
detrimental outcome in several solid tumors and new strategies to decrease their presence …

Prognostic role of pretreatment blood neutrophil-to-lymphocyte ratio in advanced cancer survivors: a systematic review and meta-analysis of 66 cohort studies

Z Mei, L Shi, B Wang, J Yang, Z Xiao, P Du… - Cancer treatment …, 2017 - Elsevier
Background Neutrophil-to-lymphocyte ratio (NLR) is crucial for the incidence and mortality of
various tumors. However, little is known on NLR and its association with prognosis in …

Change in neutrophil-to-lymphocyte ratio (NLR) in response to immune checkpoint blockade for metastatic renal cell carcinoma

AKA Lalani, W Xie, DJ Martini, JA Steinharter… - … for immunotherapy of …, 2018 - Springer
Abstract Background An elevated Neutrophil-to-lymphocyte ratio (NLR) is associated with
worse outcomes in several malignancies. However, its role with contemporary immune …

Association of systemic inflammation index and body mass index with survival in patients with renal cell cancer treated with nivolumab

U De Giorgi, G Procopio, D Giannarelli… - Clinical Cancer …, 2019 - AACR
Purpose: Inflammation indexes and body mass index (BMI) are easily evaluated, predict
survival, and are potentially modifiable. We evaluated the potential association of …

Towards individualized therapy for metastatic renal cell carcinoma

RR Kotecha, RJ Motzer, MH Voss - Nature reviews Clinical oncology, 2019 - nature.com
Over the past decade, the treatment landscape for patients with metastatic renal cell
carcinoma (RCC) has evolved dramatically. The therapeutic options available have …

Neutrophil to lymphocyte ratio predict mortality and major adverse cardiac events in acute coronary syndrome: A systematic review and meta-analysis

CH Dong, ZM Wang, SY Chen - Clinical biochemistry, 2018 - Elsevier
Objectives Neutrophil to lymphocyte ratio (NLR) might be associated with the mortality or
major adverse cardiac events (MACEs) in acute coronary syndrome (ACS) patients. We …

Neutrophil heterogeneity in cancer: from biology to therapies

P Lecot, M Sarabi, M Pereira Abrantes… - Frontiers in …, 2019 - frontiersin.org
Neutrophils have been extensively described in the pathophysiology of autoimmune and
infectious diseases. Accumulating evidence also suggests the important role of neutrophils …

Never travel alone: the crosstalk of circulating tumor cells and the blood microenvironment

S Heeke, B Mograbi, C Alix-Panabières, P Hofman - Cells, 2019 - mdpi.com
Commonly, circulating tumor cells (CTCs) are described as source of metastasis in cancer
patients. However, in this process cancer cells of the primary tumor site need to survive the …

Post-treatment neutrophil-to-lymphocyte ratio at week 6 is prognostic in patients with advanced non-small cell lung cancers treated with anti-PD-1 antibody

KJ Suh, SH Kim, YJ Kim, M Kim, B Keam… - Cancer Immunology …, 2018 - Springer
We investigated inflammatory markers such as the neutrophil-to-lymphocyte ratio (NLR) that
may predict the response to anti-PD-1 (programmed cell death protein 1) antibody therapy …

[HTML][HTML] Systemic immune-inflammation index predicts the clinical outcome in patients with metastatic renal cell cancer treated with sunitinib

C Lolli, U Basso, L Derosa, E Scarpi, T Sava… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Background In this retrospective analysis, we explored the prognostic and predictive value
of the systemic immune-inflammation index (SII), based on lymphocyte, neutrophil, and …