The diverse structural landscape of quadruplexes

HL Lightfoot, T Hagen, NJ Tatum, J Hall - FEBS letters, 2019 - Wiley Online Library
G‐quadruplexes are secondary structures formed in G‐rich sequences in DNA and RNA.
Considerable research over the past three decades has led to in‐depth insight into these …

The emerging structural complexity of G-quadruplex RNAs

MT Banco, AR Ferré-D'Amaré - Rna, 2021 - rnajournal.cshlp.org
G-quadruplexes (G4s) are four-stranded nucleic acid structures that arise from the stacking
of G-quartets, cyclic arrangements of four guanines engaged in Hoogsteen base-pairing …

RNA G-quadruplex secondary structure promotes alternative splicing via the RNA-binding protein hnRNPF

H Huang, J Zhang, SE Harvey, X Hu… - Genes & …, 2017 - genesdev.cshlp.org
It is generally thought that splicing factors regulate alternative splicing through binding to
RNA consensus sequences. In addition to these linear motifs, RNA secondary structure is …

G‐quadruplex structures and their interaction diversity with ligands

S Zhang, Y Wu, W Zhang - ChemMedChem, 2014 - Wiley Online Library
G‐Quadruplexes are distinct nucleic acid secondary structures that are formed from G‐rich
DNA and RNA sequences; they are built around successive G‐tetrads of Hoogsteen …

Automated classification of RNA 3D motifs and the RNA 3D Motif Atlas

AI Petrov, CL Zirbel, NB Leontis - Rna, 2013 - rnajournal.cshlp.org
The analysis of atomic-resolution RNA three-dimensional (3D) structures reveals that many
internal and hairpin loops are modular, recurrent, and structured by conserved non-Watson …

RNA structures in alternative splicing and back‐splicing

B Xu, Y Meng, Y Jin - Wiley Interdisciplinary Reviews: RNA, 2021 - Wiley Online Library
Alternative splicing greatly expands the transcriptomic and proteomic diversities related to
physiological and developmental processes in higher eukaryotes. Splicing of long …

[HTML][HTML] Secondary structures in RNA synthesis, splicing and translation

I Georgakopoulos-Soares, GE Parada… - Computational and …, 2022 - Elsevier
Even though the functional role of mRNA molecules is primarily decided by the nucleotide
sequence, several properties are determined by secondary structure conformations …

The G-quadruplex augments translation in the 5′ untranslated region of transforming growth factor β2

P Agarwala, S Pandey, K Mapa, S Maiti - Biochemistry, 2013 - ACS Publications
Transforming growth factor β2 (TGFβ2) is a versatile cytokine with a prominent role in cell
migration, invasion, cellular development, and immunomodulation. TGFβ2 promotes the …

[HTML][HTML] Action and function of helicases on RNA G-quadruplexes

M Caterino, K Paeschke - Methods, 2022 - Elsevier
The nucleic acid structure called G-quadruplex (G4) is currently discussed to function in
nucleic acid-based mechanisms that influence several cellular processes. They can …

Development of an In Silico Platform (TRIPinRNA) for the Identification of Novel RNA Intramolecular Triple Helices and Their Validation Using Biophysical Techniques

I Rakheja, V Bharti, S Sahana, PK Das, G Ranjan… - Biochemistry, 2025 - ACS Publications
There are surprisingly few RNA intramolecular triple helices known in the human
transcriptome. The structure has been most well-studied as a stability-element at the 3′ end …