This review considers how recent advances in the physiology of ion channels and other
potential molecular targets, in conjunction with new information on the genetics of idiopathic …

The physiological roles of the betaine/GABA transporter (BGT1; slc6a12) are still being
debated. BGT1 is a member of the solute carrier family 6 (the neurotransmitter, sodium …

The central nervous system (CNS) operates by a fine-tuned balance between excitatory and
inhibitory signalling. In this context, the inhibitory neurotransmission may be of particular …

Abstract γ-Aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the nervous
system. It plays a crucial role in many physiological processes. Upon release from the …

Background Tiagabine, a selective inhibitor of GABA transporter subtype 1 is used as an
add-on therapy of partial seizures in humans but its mechanism of action suggests other …

Müller cells represent the main type of glia present in the retina interacting with most, if not
all neurons in this tissue. Müller cells have been claimed to function as optic fibers in the …

Abstract ɣ-aminobutyric-acid (GABA) functions as the principal inhibitory neurotransmitter in
the central nervous system. Imbalances in GABAergic neurotransmission are involved in the …

Inactivation of GABA-mediated neurotransmission is achieved by high-affinity transporters
located at both GABAergic neurons and the surrounding astrocytes. Early studies of the …

For more than four decades there has been a search for selective inhibitors of GABA
transporters. This has led to potent and selective inhibitors of the cloned GABA transporter …

Plasma membrane γ-aminobutyric acid (GABA) transporters act to terminate GABA
neurotransmission in the mammalian brain. Intriguingly four distinct GABA transporters have …