SA Kempson, Y Zhou, NC Danbolt - Frontiers in physiology, 2014 - frontiersin.org
The physiological roles of the betaine/GABA transporter (BGT1; slc6a12) are still being debated. BGT1 is a member of the solute carrier family 6 (the neurotransmitter, sodium …
A Schousboe, HS Waagepetersen - Progress in brain research, 2007 - Elsevier
The central nervous system (CNS) operates by a fine-tuned balance between excitatory and inhibitory signalling. In this context, the inhibitory neurotransmission may be of particular …
K Łątka, J Jończyk, M Bajda - International journal of biological …, 2020 - Elsevier
Abstract γ-Aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the nervous system. It plays a crucial role in many physiological processes. Upon release from the …
K Sałat, A Podkowa, P Kowalczyk, K Kulig… - Pharmacological …, 2015 - Elsevier
Background Tiagabine, a selective inhibitor of GABA transporter subtype 1 is used as an add-on therapy of partial seizures in humans but its mechanism of action suggests other …
Müller cells represent the main type of glia present in the retina interacting with most, if not all neurons in this tissue. Müller cells have been claimed to function as optic fibers in the …
S Kickinger, E Hellsberg, B Frølund, A Schousboe… - …, 2019 - Elsevier
Abstract ɣ-aminobutyric-acid (GABA) functions as the principal inhibitory neurotransmitter in the central nervous system. Imbalances in GABAergic neurotransmission are involved in the …
A Schousboe, P Wellendorph, B Frølund… - Glial Amino Acid …, 2017 - Springer
Inactivation of GABA-mediated neurotransmission is achieved by high-affinity transporters located at both GABAergic neurons and the surrounding astrocytes. Early studies of the …
S Hog, JR Greenwood, KB Madsen… - Current topics in …, 2006 - ingentaconnect.com
For more than four decades there has been a search for selective inhibitors of GABA transporters. This has led to potent and selective inhibitors of the cloned GABA transporter …
B Christiansen, AK Meinild, AA Jensen… - Journal of Biological …, 2007 - ASBMB
Plasma membrane γ-aminobutyric acid (GABA) transporters act to terminate GABA neurotransmission in the mammalian brain. Intriguingly four distinct GABA transporters have …