An increase in fat mass is considered to be an important risk factor for the worldwide
increase in type 2 diabetes and cardiovascular disease. However, for a given fat mass, there …

The manner in which white adipose tissue (WAT) expands and remodels directly impacts the
risk of developing metabolic syndrome in obesity. Preferential accumulation of visceral WAT …

To date, single-cell studies of human white adipose tissue (WAT) have been based on small
cohort sizes and no cellular consensus nomenclature exists. Herein, we performed a …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

While obesity and associated metabolic complications are linked to inflammation of white
adipose tissue (WAT), the causal factors remain unclear. We hypothesized that the local …

Reducing body weight to improve metabolic health and related comorbidities is a primary
goal in treating obesity,. However, maintaining weight loss is a considerable challenge …

Dietary restriction (DR) during adulthood can greatly extend lifespan and improve metabolic
health in diverse species. However, whether DR in mammals is still effective when applied …

The mechanisms promoting disturbed white adipocyte function in obesity remain largely
unclear. Herein, we integrate white adipose tissue (WAT) metabolomic and transcriptomic …

Recent technological developments have allowed determination of the age of fat cells and
their lipids in adult humans. In contrast to prior views, this has demonstrated a high turnover …

Postprandial IL-1β surges are predominant in the white adipose tissue (WAT), but its
consequences are unknown. Here, we investigate the role of IL-1β in WAT energy storage …