Natural bioactive peptide discovery is a challenging and time-consuming process. However,
advances in synthetic biology are providing promising new avenues in peptide engineering …

Recently, owing to their special spatial structures, peptide-based macrocycles have shown
tremendous promise and aroused great interest in multidisciplinary research ranging from …

LanD flavoproteins catalyze oxidative decarboxylation of the C‐terminal Cys residue of a
peptide to produce an enethiol. This enethiol is highly reactive and can be coupled with an …

Thioholgamides are ribosomally synthesized and posttranslationally modified peptides
(RiPPs), with potent activity against cancerous cell lines and an unprecedented structure …

Lanthipeptides are ribosomally synthesized and post-translationally modified peptide
natural products characterized by the presence of lanthionine and methyllanthionine cross …

Linaridins and lanthipeptides are two classes of natural products belonging to the
ribosomally synthesized and posttranslationally modified peptide (RiPP) superfamily …

Thioaldehyde is a highly electrophilic group under aqueous conditions and can be
generated via oxidative enzymatic modifications of cysteine residues in peptides and …

L-Cysteine is a highly reactive amino acid that is modified into a variety of chemical
structures, including cysteine sulfinic acid in human metabolic pathways, and sulfur …

Antimicrobial resistance remains a significant global threat, driving up mortality rates
worldwide. Ribosomally synthesized and post-translationally modified peptides have …

Thiostreptamide S4 is a thioamitide, a family of promising antitumour ribosomally
synthesised and post-translationally modified peptides (RiPPs). The thioamitides are one of …