Macrocyclic structures are common synthetic targets in drug discovery,(1, 2) and therefore,
interest in their study is continuously increasing in this field.(3, 4) A classic example is …

The early effectiveness of combinatorial antiretroviral therapy (cART) in the treatment of HIV
infection has been compromised to some extent by rapid development of multidrug-resistant …

Anti-synthetase syndrome (ASSD) is an autoimmune disease characterized by the presence
of autoantibodies targeting one of several aminoacyl t-RNA synthetases (aaRSs) along with …

Macrocyclic compounds such as cyclic peptides have emerged as a new and exciting class
of drug candidates for inhibition of intracellular protein–protein interactions, which are …

Cyclic heptapeptide cyclo (FΦRRRRQ)(cFΦR4, where Φ is l-2-naphthylalanine) was
recently found to be efficiently internalized by mammalian cells. In this study, its mechanism …

Aminoacyl-tRNA synthetases (ARSs) play a vital role in protein synthesis by linking amino
acids to their cognate transfer RNAs (tRNAs). This typical function has been well recognized …

Protein–protein interactions represent a new class of exciting but challenging drug targets,
because their large, flat binding sites lack well-defined pockets for small molecules to bind …

The lifecycle of retroviruses and retrotransposons includes a reverse transcription step,
wherein dsDNA is synthesized from genomic RNA for subsequent insertion into the host …

Backbone macrocyclic structures are often found in diverse bioactive peptides and
contribute to greater conformational rigidity, peptidase resistance, and potential membrane …

Cyclic peptides are a promising class of molecules that can be used to target specific protein–
protein interactions. A computational method to accurately predict their structures would …