Geroscience is becoming a major hope for preventing age-related diseases and loss of
function by targeting biological mechanisms of aging. This unprecedented paradigm shift …

Oxidative stress develops as a response to injury and reflects a breach in the cell's
antioxidant capacity. Therefore, the fine-tuning of reactive oxygen species (ROS) generation …

Understanding the complex dynamics of telomere biology is important in the strong link
between aging and cancer. Telomeres, the protective caps at the end of chromosomes, are …

The existence of a sex gap in human health and longevity has been widely documented.
Autosomal DNA methylation differences between males and females have been reported …

Down syndrome is the most common chromosomal disorder, associated with moderate to
severe intellectual disability. While life expectancy of Down syndrome population has greatly …

Immunoglobulin G (IgG) antibodies are post-translationally modified by the addition of
complex carbohydrate molecules–glycans, which have profound effects on the IgG function …

Although the trigger for the neurodegenerative disease process is unknown, the relevance
of aging stands out as a major risk for the development of neurodegeneration. In this review …

Abstract Background Neurodevelopmental disorders (NDDs) such as autism spectrum
disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and Down syndrome (DS) …

Highlights•Nanosponges are explored for their antiviral delivery and biological
neutralization potentials.•Cellular nanosponges block interactions between SARS-CoV-2 …

The regenerative potential of neural stem cells (NSCs) declines during aging, leading to
cognitive dysfunctions. This decline involves up-regulation of senescence-associated …