Pyrrole is a heterocyclic ring template with multiple pharmacophores that provides a way for
the generation of library of enormous lead molecules. Owing to its vast pharmacological …

Human immunodeficiency virus (HIV) and Mycobacterium tuberculosis (Mtb) are pathogens
responsible for millions of new infections each year; together, they cause high morbidity and …

Despite wide antiretroviral scale-up during the past two decades resulting in declining new
infections and mortality globally, HIV-associated tuberculosis remains as a major public …

Tuberculosis is a severe disease affecting millions worldwide. Unfortunately, treatment
strategies are hampered both by the prohibitively long treatment regimen and the rise of …

The discovery of small organic molecules as new antimicrobial agents is a promising
strategy for encountering the problem of multidrug-resistant microbial strains. In an attempt …

Background Tuberculosis (TB) is the leading cause of death for individuals infected with
Human immunodeficiency virus (HIV). Conversely, HIV is the most important risk factor in the …

Mucosal-associated invariant T (MAIT) cells are evolutionarily conserved antimicrobial MR1-
restricted CD8+ T cells co-expressing the semi-invariant TCR Vα7. 2, and are numerous in …

The association of tuberculosis (TB) with human immunodeficiency virus (HIV) infection and
acquired immune deficiency syndrome over the past several years has become an …

Background Despite reported long delays to initiate anti-TB treatment and poor outcomes in
different parts of Ethiopia and elsewhere, evidences on association between the delay and …

To survive and replicate in macrophages Mycobacterium tuberculosis (Mtb) has developed
strategies to subvert host defence mechanisms, including autophagy. Autophagy induction …