Conspectus Although macrocyclic peptides bearing exotic building blocks have proven their
utility as pharmaceuticals, the sources of macrocyclic peptide drugs have been largely …

Thiopeptides (also known as thiazolyl peptides) are structurally complex natural products
with rich biological activities. Known for over 70 years for potent killing of Gram-positive …

Ribosome-mediated polymerization of backbone-extended monomers into polypeptides is
challenging due to their poor compatibility with the translation apparatus, which evolved to …

The ribosome is a macromolecular machine that catalyzes the sequence-defined
polymerization of L-α-amino acids into polypeptides. The catalysis of peptide bond formation …

2-Aminobenzoic acid and heterocyclic amino acids are aromatic homologues of β-amino
acids, but their chemical properties are quite distinct. Because of the poor nucleophilicity of …

Macrocyclic peptides are a promising class of compounds that can often engage
challenging therapeutic targets. Display technologies, such as mRNA display, allow for the …

As a major class of foldamers, aromatic oligoamide foldamers have attracted intense
interest. The rigidity of aromatic residues and amide linkages allows the development of …

Transfer RNAs have been extensively explored as the molecules that translate the genetic
code into proteins. At this interface of genetics and biochemistry, tRNAs direct the efficiency …

Dynamic DNA nanodevices-based assembly is currently well developed for a broad range
of analytical applications. However, some problems persist, such as false positives …

Ribosome-dependent protein biosynthesis is an essential cellular process mediated by
transfer RNAs (tRNAs). Generally, ribosomally synthesized proteins are limited to the 22 …