Bisphosphonates (BPs) are highly effective in treating osteoporosis and reducing hip,
vertebral, and other fractures by as much as 50% to 70%. However, since 2006, atypical …

Bisphosphonates (BP) are a class of calcium-binding drug used to prevent bone resorption
in skeletal disorders such as osteoporosis and metastatic bone disease. They act by …

Abstract The bisphosphonates ((HO) 2 P (O) CR 1 R 2 P (O)(OH) 2, BPs) were first shown to
inhibit bone resorption in the 1960s, but it was not until 30 years later that a detailed …

Abstract Purpose of Review To summarize reports published since the 2013 American
Society of Bone and Mineral Research Task Force Report on atypical femoral fractures …

Geranylgeranyl diphosphate synthase (GGDPS), an enzyme in the isoprenoid biosynthesis
pathway, is responsible for the production of geranylgeranyl pyrophosphate (GGPP). GGPP …

Atypical femoral fractures (AFFs) are uncommon and have been associated particularly with
long term antiresorptive therapy, including bisphosphonates. Although the pathogenesis of …

Abstract Purpose of Review Atypical femur fractures (AFFs) are rare subtrochanteric or
diaphyseal fractures regarded as side effects of bisphosphonates (BPs), possibly with a …

Atypical femoral fractures (AFF) are stress or 'insufficiency'fractures, often complicated by the
use of bisphosphonates or other bone turnover inhibitors. While these drugs are beneficial …

Perrault syndrome is a rare heterogeneous condition characterised by sensorineural
hearing loss and premature ovarian insufficiency. Additional neuromuscular pathology is …

Nitrogen-containing-bisphosphonates (N-BPs) are a class of drugs widely prescribed to treat
osteoporosis and other bone-related diseases. Although previous studies have established …