Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …

The molecular components of the postsynaptic density (PSD) in excitatory synapses of the
brain are currently being investigated as one of the major etiologies of neurodevelopmental …

The postsynaptic side of the synapse is specialized to receive the neurotransmitter signal
released from the presynaptic terminal and transduce it into electrical and biochemical …

The postsynaptic density (PSD)-95 family of membrane-associated guanylate kinases
(MAGUKs) are major scaffolding proteins at the PSD in glutamatergic excitatory synapses …

The tight junction protein ZO-1 belongs to a family of multidomain proteins known as the
membrane-associated guanylate kinase homologs (MAGUKs). ZO-1 has been …

PDZ domains are protein-interaction domains that are often found in multi-domain
scaffolding proteins. PDZ-containing scaffolds assemble specific proteins into large …

A fundamental function of epithelia and endothelia is to separate different compartments
within the organism and to regulate the exchange of substances between them. The tight …

The process by which extracellular signals are relayed from the plasma membrane to
specific intracellular sites is an essential facet of cellular regulation. Many signaling …

NMDA receptors are linked to intracellular cytoskeletal and signaling molecules via the PSD-
95 protein complex. We report a novel family of postsynaptic density (PSD) proteins, termed …

ZO-1, ZO-2, and ZO-3, which contain three PDZ domains (PDZ1 to-3), are concentrated at
tight junctions (TJs) in epithelial cells. TJ strands are mainly composed of two distinct types …