Nanoparticle-based drug delivery for the treatment of traumatic brain injury

FS Mohammed, SB Omay, KN Sheth… - Expert opinion on drug …, 2023 - Taylor & Francis
ABSTRACT Introduction Traumatic brain injuries (TBIs) impact the breadth of society and
remain without any approved pharmacological treatments. Despite successful Phase II …

Local delivery of dual stem cell-derived exosomes using an Electrospun Nanofibrous platform for the treatment of traumatic brain injury

J Li, X Li, X Li, Z Liang, Z Wang… - … Applied Materials & …, 2024 - ACS Publications
Traumatic brain injury poses serious physical, psychosocial, and economic threats. Although
systemic administration of stem cell-derived exosomes has recently been proven to be a …

Nanocarrier-mediated siRNA delivery: a new approach for the treatment of traumatic brain injury–related Alzheimer's disease

J Jin, H Zhang, Q Lu, L Tian, S Yao, F Lai… - Neural Regeneration …, 2025 - journals.lww.com
Traumatic brain injury and Alzheimer's disease share pathological similarities, including
neuronal loss, amyloid-β deposition, tau hyperphosphorylation, blood–brain barrier …

The chronic effects of a single low-intensity blast exposure on Phosphoproteome networks and cognitive function influenced by mutant tau overexpression

M Jackson, S Chen, TT Nguyen, HR Siedhoff… - International Journal of …, 2024 - mdpi.com
Blast-induced neurotrauma (BINT) is a pressing concern for veterans and civilians exposed
to explosive devices. Affected personnel may have increased risk for long-term cognitive …

Overexpress miR-132 in the Brain Parenchyma by a Non-invasive Way Improves Tissue Repairment and Releases Memory Impairment After Traumatic Brain Injury

M Jia, X Guo, R Liu, L Sun, Q Wang, J Wu - Cellular and Molecular …, 2024 - Springer
Traumatic brain injury (TBI) is a serious public health problem worldwide, which could lead
to an extremely high percentage of mortality and disability. Current treatment strategies …

FYN as an emerging biological biomarker for prognosis and potential therapeutic target in LGG

J Zhu, L Shi, Y Su - Neurological Research, 2024 - Taylor & Francis
Objectives This study aimed to explore the expression, clinical significance, and functional
mechanism of FYN in lower-grade gliomas (LGG). Methods The mRNA and protein …

Brain-derived neurotrophic factor regulates LYN kinase–mediated myosin light chain kinase activation to modulate nonmuscle myosin II activity in hippocampal …

X Li, RR Yuan, Q Wang, S Chai, Z Zhang… - Journal of Biological …, 2022 - ASBMB
Myosins belong to a large superfamily of actin-dependent molecular motors. Nonmuscle
myosin II (NM II) is involved in the morphology and function of neurons, but little is known …

Multi-targeted anti-inflammatory drugs for the treatment of neurological disorders

A Lui, O Alzayat, T Do, D Perekopskiy… - Neural Regeneration …, 2023 - journals.lww.com
Inflammation and kinase pathophysiology in neurological disorders: Inflammation is one of
the common features of various acute and degenerative neurological disorders, such as …

FDA-approved kinase inhibitors: a promising therapeutic avenue for traumatic brain injury

D Gao, Y Shi, Z Wang, W Liu - Exploration of Drug Science, 2024 - explorationpub.com
Traumatic brain injury (TBI) is a complex disease that leads to significant mortality and
disability worldwide each year. TBI disrupts the normal activity of kinases and molecular …

[PDF][PDF] Nanocarrier-mediated siRNA delivery: a prospective amyloid precursor proteinroach for traumatic brain injury-related Alzheimer's pathology

J Jin, H Zhang, Q Lu, L Tian, S Yao, F Lai, Y Liang… - sjzsyj.com.cn
Traumatic brain injury (TBI) is a prevalent neurological disorder linked to neurodegenerative
diseases such as Alzheimer's disease (AD). TBI and AD share pathological similarities …