Streptozotocin (STZ) is the most used diabetogenic chemical for creating rat models of type
1 and type 2 diabetes. Despite~ 60 years of using STZ in animal diabetes research, some …

Streptozotocin (STZ) has been extensively used over the last three decades to induce
diabetes in various animal species and to help screen for hypoglycemic drugs. STZ induces …

Zinc oxide (ZnO) nanoparticles (NPs) have been synthesized using Hibiscus subdariffa leaf
extract. Temperature dependent synthesis and particle growth have been studied. Formation …

Alloxan and streptozotocin are widely used to induce experimental diabetes in animals. The
mechanism of their action in B cells of the pancreas has been intensively investigated and …

Diabetes mellitus is a chronic metabolic disorder with a high prevalence worldwide. Animal
models of diabetes represent an important tool in diabetes investigation that helps us to …

Alloxan and streptozotocin are toxic glucose analogues that preferentially accumulate in
pancreatic beta cells via the GLUT2 glucose transporter. In the presence of intracellular …

The global prevalence of prediabetes and type 2 diabetes (T2D) is increasing, and it is
contributing to the susceptibility to diabetes and its related epidemic in offspring. Although …

Administration of both streptozotocin (STZ) and nicotinamide (NA) has been proposed to
induce experimental diabetes in the rat. STZ is well known to cause pancreatic B-cell …

Antioxidant enzyme expression was determined in rat pancreatic islets and RINm5F insulin-
producing cells on the level of mRNA, protein, and enzyme activity in comparison with 11 …

Recently, loss of beta-cell-specific traits has been proposed as an early cause of beta cell
failure in diabetes. However, the molecular mechanisms that underlie the loss of beta cell …