Designing cancer immunotherapies that engage T cells and NK cells

O Kyrysyuk, KW Wucherpfennig - Annual review of immunology, 2023 - annualreviews.org
T cells and natural killer (NK) cells have complementary roles in tumor immunity, and dual T
cell and NK cell attack thus offers opportunities to deepen the impact of immunotherapy …

Tumor-infiltrating natural killer cells

B Cózar, M Greppi, S Carpentier, E Narni-Mancinelli… - Cancer discovery, 2021 - AACR
Because of their potent antitumor activity and their proinflammatory role, natural killer (NK)
cells are at the forefront of efforts to develop immuno-oncologic treatments. NK cells …

Transfer learning enables predictions in network biology

CV Theodoris, L Xiao, A Chopra, MD Chaffin… - Nature, 2023 - nature.com
Mapping gene networks requires large amounts of transcriptomic data to learn the
connections between genes, which impedes discoveries in settings with limited data …

A pan-cancer single-cell panorama of human natural killer cells

F Tang, J Li, L Qi, D Liu, Y Bo, S Qin, Y Miao, K Yu… - Cell, 2023 - cell.com
Natural killer (NK) cells play indispensable roles in innate immune responses against tumor
progression. To depict their phenotypic and functional diversities in the tumor …

The NK cell–cancer cycle: advances and new challenges in NK cell–based immunotherapies

T Bald, MF Krummel, MJ Smyth, KC Barry - Nature immunology, 2020 - nature.com
Natural killer (NK) cells belong to the innate immune system and contribute to protecting the
host through killing of infected, foreign, stressed or transformed cells. Additionally, via …

[HTML][HTML] NK cells and ILCs in tumor immunotherapy

S Sivori, D Pende, L Quatrini, G Pietra… - Molecular aspects of …, 2021 - Elsevier
Cells of the innate immunity play an important role in tumor immunotherapy. Thus, NK cells
can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity …

Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment

G Werba, D Weissinger, EA Kawaler, E Zhao… - Nature …, 2023 - nature.com
The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) is a
complex ecosystem that drives tumor progression; however, in-depth single cell …

Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping

H Netskar, A Pfefferle, JP Goodridge, E Sohlberg… - Nature …, 2024 - nature.com
The functional diversity of natural killer (NK) cell repertoires stems from differentiation,
homeostatic, receptor–ligand interactions and adaptive-like responses to viral infections. In …

[PDF][PDF] Antibody-drug conjugates in breast cancer: overcoming resistance and boosting immune response

HL Chang, B Schwettmann… - Journal of Clinical …, 2023 - Am Soc Clin Investig
Antibody-drug conjugates (ADCs) have emerged as a revolutionary therapeutic class,
combining the precise targeting ability of monoclonal antibodies with the potent cytotoxic …

A single-cell analysis reveals tumor heterogeneity and immune environment of acral melanoma

C Zhang, H Shen, T Yang, T Li, X Liu, J Wang… - Nature …, 2022 - nature.com
Acral melanoma is a dismal subtype of melanoma occurring in glabrous acral skin, and has
a higher incidence in East Asians. We perform single-cell RNA sequencing for 63,394 cells …