The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected …

Abstract mRNA technology has emerged as a successful vaccine platform that offered a swift
response to the COVID-19 pandemic. Accumulating evidence shows that vaccine efficacy …

Most deaths from the COVID-19 pandemic are due to acute respiratory distress syndrome
(ARDS)-related respiratory failure. Cytokine storms and oxidative stress are the major …

In order to gain a deeper understanding of the recently emerged and highly divergent
Omicron variant of concern (VoC), a study of amino acid substitution (AAS) patterns was …

The emergence of the SARS-CoV-2 Omicron variant poses a striking threat to human
society. More than 30 mutations in the Spike protein of the Omicron variant severely …

Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a poor inducer of innate
antiviral immunity, and the underlying mechanism still needs further investigation. Here, we …

Taking advantage of the uniquely constricted active site of SARS-CoV-2 Nsp14
methyltransferase, we have designed bisubstrate inhibitors interacting with the SAM and …

Abstract Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) 1. The rapid development of highly effective …

The recent coronavirus disease 2019 (COVID-19) pandemic was caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is characterized by …

Live-attenuated SARS-CoV-2 vaccines received relatively little attention during the COVID-
19 pandemic. Despite this, several methods of obtaining attenuated coronaviruses are …