The immune system is closely linked to bone homeostasis and plays a pivotal role in several
pathological and inflammatory conditions. Through various pathways it modulates various …

Background Osteolytic diseases share symptoms such as bone loss, fracture and pain,
which are caused by over-activated osteoclasts. Targeting osteoclast differentiation has …

Milk fat globule-epidermal growth factor (EGF) factor 8 (MFG-E8), as a necessary bridging
molecule between apoptotic cells and phagocytic cells, has been widely studied in various …

Background Scar tissue formation at the tendon-bone interface caused by excessive
inflammation leads to insufficient healing strength, while the phagocytic clearance of dying …

Extensive phytochemical investigation of the seeds of Tripterygium wilfordii led to the
identification of 54 polyesterified dihydro-β-agarofuran-type sesquiterpenoids, including 27 …

Parathyroid hormone (PTH) is produced by the parathyroid glands in response to low serum
calcium concentrations where it targets bones, kidneys, and indirectly, intestines. The N …

Ineffective oral wound healing is detrimental to patients' oral health–related quality of life.
Delineating the cellular mechanisms involved in optimal healing will elicit better approaches …

Stem cells provide clues to why vertebrae attract tumour cells Skip to main content Thank you
for visiting nature.com. You are using a browser version with limited support for CSS. To obtain …

Spinal cord injury (SCI) is a common disease and a major cause of paralysis, carrying much
burden around the world. Despite the progress made with growth factors therapy, the …

Background: Osteoporosis (OS) and fractures are common in patients with end-stage renal
disease (ESRD) and maintenance dialysis patients. However, diagnosing osteoporosis in …