Estrogen receptors alpha (ERα) and beta (ERβ): subtype-selective ligands and clinical potential
I Paterni, C Granchi, JA Katzenellenbogen, F Minutolo - Steroids, 2014 - Elsevier
Estrogen receptors alpha (ERα) and beta (ERβ) are nuclear transcription factors that are
involved in the regulation of many complex physiological processes in humans. Modulation …
involved in the regulation of many complex physiological processes in humans. Modulation …
Biological importance of structurally diversified chromenes
Compounds incorporating the chromene scaffold are largely present in natural products and
display a wide variety of biological activities. Their low toxicity combined to the broad …
display a wide variety of biological activities. Their low toxicity combined to the broad …
The discovery and development of selective estrogen receptor modulators (SERMs) for clinical practice
P Y. Maximov, T M. Lee… - Current clinical …, 2013 - benthamdirect.com
Selective estrogen receptor modulators (SERMs) are structurally different compounds that
interact with intracellular estrogen receptors in target organs as estrogen receptor agonists …
interact with intracellular estrogen receptors in target organs as estrogen receptor agonists …
Design and evaluation of sulfadiazine derivatives as potent dual inhibitors of EGFR WT and EGFR T790M: integrating biological, molecular docking, and ADMET …
A series of derivatives (5–14) were synthesized through the diazotization of sulfadiazine with
active methylene compounds. The chemical structures of these newly designed compounds …
active methylene compounds. The chemical structures of these newly designed compounds …
Vanillin-based indolin-2-one derivative bearing a pyridyl moiety as a promising anti-breast cancer agent via anti-estrogenic activity
The structure-based design introduced indoles as an essential motif in designing new
selective estrogen receptor modulators employed for treating breast cancer. Therefore, here …
selective estrogen receptor modulators employed for treating breast cancer. Therefore, here …
A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice
MW Boudreau, D Duraki, L Wang, C Mao… - Science translational …, 2021 - science.org
Metastatic estrogen receptor α (ERα)–positive breast cancer is presently incurable. Seeking
to target these drug-resistant cancers, we report the discovery of a compound, called ErSO …
to target these drug-resistant cancers, we report the discovery of a compound, called ErSO …
Amine-functionalized silica-supported magnetic nanoparticles: preparation, characterization and catalytic performance in the chromene synthesis
A Maleki, S Azadegan - Journal of Inorganic and Organometallic Polymers …, 2017 - Springer
An efficient, one-pot multicomponent procedure for good to excellent yield preparation of 2-
amino-4 H-chromene-4-carboxylate and 2-amino-5 H-pyrano [3, 2-c] chromene-4 …
amino-4 H-chromene-4-carboxylate and 2-amino-5 H-pyrano [3, 2-c] chromene-4 …
Design of New Benzo[h]chromene Derivatives: Antitumor Activities and Structure-Activity Relationships of the 2,3-Positions and Fused Rings at the 2,3-Positions
A series of novel 4 H-benzo [h] chromenes 4, 6–11, 13, 14; 7 H-benzo [h] chromeno [2, 3-d]
pyrimidines 15–18, 20, and 14 H-benzo [h] chromeno [3, 2-e][1, 2, 4] triazolo [1, 5-c] …
pyrimidines 15–18, 20, and 14 H-benzo [h] chromeno [3, 2-e][1, 2, 4] triazolo [1, 5-c] …
First example of Azo-Sulfa conjugated chromene moieties: Synthesis, characterization, antimicrobial assessment, docking simulation as potent class I histone …
This report presents the development of a novel and primary model of sulfonamide
compounds encompassing a chromene azo motif with the intent of becoming applicable for …
compounds encompassing a chromene azo motif with the intent of becoming applicable for …
[HTML][HTML] Structure-activity relationships and molecular docking studies of chromene and chromene based azo chromophores: A novel series of potent antimicrobial …
The design of novel materials with significant biological properties is a main target in drug
design research. Chromene compounds represent an interesting medicinal scaffold in drug …
design research. Chromene compounds represent an interesting medicinal scaffold in drug …