Understanding human pre-implantation development has important implications for assisted
reproductive technology (ART) and for human embryonic stem cell (hESC)-based therapies …

BACKGROUND The media that are used to culture human preimplantation embryos are
considered to be an important factor for the success rates of IVF/ICSI. Here, we present a …

Although genetically identical for autosomal Chrs (Chr), male and female preimplantation
embryos could display sex-specific transcriptional regulation. To illustrate sex-specific …

The Developmental Origins of Health and Disease hypothesis holds that alterations to
homeostasis during critical periods of development can predispose individuals to adult …

Assisted reproductive technology (ART) has led to the birth of millions of babies. In cattle,
thousands of embryos are produced annually. However, since the introduction and …

Development of assisted reproductive technologies has been driven by the goals of
reducing the incidence of infertility, increasing the number of offspring from genetically elite …

Epigenetics, and in particular imprinted genes, have a critical role in the development and
function of the placenta, which in turn has a central role in the regulation of fetal growth and …

More than 4.5 million children have been conceived by in vitro fertilization (IVF).
Interestingly, singleton IVF offspring born at term have an increased incidence of low birth …

Formation of a totipotent blastocyst capable of implantation is one of the first major
milestones in early mammalian embryogenesis, but less than half of in vitro fertilized …

Since the birth of the first IVF-conceived child in 1978, the use of assisted reproductive
technologies (ART) has grown dramatically, contributing to the successful birth of 5 million …