Chalcones (1, 3-diaryl-2-propen-1-ones) are precursors for flavonoids and isoflavonoids,
which are common simple chemical scaffolds found in many naturally occurring compounds …

The need for innovative anticancer treatments with high effectiveness and low toxicity is
urgent due to the development of malignancies that are resistant to chemotherapeutic …

Microtubules play an important role in the process of cell mitosis and can form a spindle in
the mitotic prophase of the cell, which can pull chromosomes to the ends of the cell and then …

Topoisomerases II are ubiquitous enzymes with significant genotoxic effects in many critical
DNA processes. Additionally, epidermal growth factor receptor (EGFR) plays pivotal role in …

Novel dual HDAC3/tubulin inhibitors were designed and efficiently synthesized by
combining the pharmacophores of SMART (tubulin inhibitor) and MS-275 (HDAC inhibitor) …

Histone deacetylases (HDACs) play a key role in the homeostasis of protein acetylation in
histones and have recently emerged as a therapeutic target for numerous diseases. The …

The present study established thirteen novel 8-hydroxyquinoline/chalcone hybrids 3a–m of
hopeful anticancer activity. According to NCI screening and MTT assay results, compounds …

In the landscape of epigenetic regulation, histone deacetylase 3 (HDAC3) has emerged as a
prominent therapeutic target for the design and development of candidate drugs against …

Most vascular disrupting agents (VDAs) fail to prevent the regrowth of blood vessels at the
edge of tumors, causing tumor rebound and relapse. Herein, a series of novel …

A novel series of cis-diphenylethene and benzophenone derivatives as tubulin/HDAC dual-
targeting inhibitors were designed and synthesized. Among them, compound 28g exhibited …