Platelets are anucleate cells produced by megakaryocytes. In recent years, a robust body of
literature supports the evolving role of platelets as key sentinel and effector cells in infectious …

Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …

Endothelial cell (EC) activation plays a key role in the pathogenesis of pulmonary
microvascular occlusion, which is a hallmark of severe coronavirus disease 2019 (COVID …

Endothelial dysfunction contributes to the pathogenesis of a variety of potentially serious
infectious diseases and syndromes, including sepsis and septic shock, hemolytic-uremic …

Pathogenesis of thrombotic thrombocytopenic purpura (TTP) was a mystery for over half a
century until the discovery of ADAMTS13. ADAMTS13 is primarily synthesized in the liver …

Normal hemostasis requires von Willebrand factor (VWF) to support platelet adhesion and
aggregation at sites of vascular injury. VWF is a multimeric glycoprotein built from identical …

Severe malaria caused by Plasmodium falciparum is difficult to diagnose accurately in
children in high-transmission settings. Using data from 2649 pediatric and adult patients …

Vivax malaria was historically described as 'benign tertian malaria'because individual
clinical episodes were less likely to cause severe illness than Plasmodium falciparum …

Coevolution of humans and malaria parasites has generated an intricate balance between
the immune system of the host and virulence factors of the parasite, equilibrating maximal …

Von Willebrand factor (VWF) is a multimeric procoagulant plasma glycoprotein that mediates
platelet adhesion along the endothelium. In addition to its role maintaining normal …