Remodeling and Fibrosis of the Cardiac Muscle in the Course of Obesity—Pathogenesis and Involvement of the Extracellular Matrix

J Kruszewska, A Cudnoch-Jedrzejewska… - International Journal of …, 2022 - mdpi.com
Obesity is a growing epidemiological problem, as two-thirds of the adult population are
carrying excess weight. It is a risk factor for the development of cardiovascular diseases …

PCSK9 promotes cardiovascular diseases: recent evidence about its association with platelet activation-induced myocardial infarction

MU Puteri, NU Azmi, M Kato, FC Saputri - Life, 2022 - mdpi.com
Cardiovascular diseases are the leading cause of death worldwide, with the majority of the
cases being heart failure due to myocardial infarction. Research on cardiovascular diseases …

[HTML][HTML] WTAP promotes myocardial ischemia/reperfusion injury by increasing endoplasmic reticulum stress via regulating m6A modification of ATF4 mRNA

J Wang, J Zhang, Y Ma, Y Zeng, C Lu, F Yang… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Myocardial infarction (MI) is one of the leading causes of death. Wilms' tumor 1-associating
protein (WTAP), one of the components of the m 6 A methyltransferase complex, has been …

Wearable real-time heart attack detection and warning system to reduce road accidents

MEH Chowdhury, K Alzoubi, A Khandakar, R Khallifa… - Sensors, 2019 - mdpi.com
Heart attack is one of the leading causes of human death worldwide. Every year, about
610,000 people die of heart attack in the United States alone—that is one in every four …

HIF-1α-regulated lncRNA-TUG1 promotes mitochondrial dysfunction and pyroptosis by directly binding to FUS in myocardial infarction

YW Wang, HZ Dong, YX Tan, X Bao, YM Su, X Li… - Cell death …, 2022 - nature.com
Myocardial infarction (MI) is a fatal heart disease that affects millions of lives worldwide each
year. This study investigated the roles of HIF-1α/lncRNA-TUG1 in mitochondrial dysfunction …

Localized delivery of anti-inflammatory agents using extracellular matrix-nanostructured lipid carriers hydrogel promotes cardiac repair post-myocardial infarction

X Wang, H Shi, S Huang, Y Zhang, X He, Q Long… - Biomaterials, 2023 - Elsevier
A challenge in treating cardiac injury is the low heart-specificity of the drugs. Nanostructured
lipid carriers (NLCs) are a relatively new format of lipid nanoparticles which have been used …

Heart‐on‐a‐Chip Model of Epicardial–Myocardial Interaction in Ischemia Reperfusion Injury

D Bannerman, S Pascual‐Gil, Q Wu… - Advanced …, 2024 - Wiley Online Library
Epicardial cells (EPIs) form the outer layer of the heart and play an important role in
development and disease. Current heart‐on‐a‐chip platforms still do not fully mimic the …

Knockdown of deleterious miRNA in progenitor cell–derived small extracellular vesicles enhances tissue repair in myocardial infarction

HJ Park, JR Hoffman, ME Brown, S Bheri… - Science …, 2023 - science.org
Small extracellular vesicles (sEVs) play a critical role in cardiac cell therapy by delivering
molecular cargo and mediating cellular signaling. Among sEV cargo molecule types …

NLRP3 inflammasome in cardiovascular diseases: pathophysiological and pharmacological implications

C Pellegrini, A Martelli, L Antonioli… - Medicinal Research …, 2021 - Wiley Online Library
Growing evidence points out the importance of nucleotide‐binding oligomerization domain
leucine‐rich repeat and pyrin domain‐containing protein 3 (NLRP3) inflammasome in the …

[HTML][HTML] Cardiac tissue engineering for myocardial infarction treatment

P Gil-Cabrerizo, I Scacchetti, E Garbayo… - European Journal of …, 2023 - Elsevier
Myocardial infarction is one of the major causes of morbidity and mortality worldwide.
Current treatments can relieve the symptoms of myocardial ischemia but cannot repair the …