Eugenol and lidocaine inhibit voltage-gated Na+ channels from dorsal root ganglion neurons with different mechanisms

L Moreira-Junior, JH Leal-Cardoso… - Frontiers in …, 2024 - frontiersin.org
Eugenol (EUG) is a bioactive monoterpenoid used as an analgesic, preservative, and
flavoring agent. Our new data show EUG as a voltage-gated Na+ channel (VGSC) inhibitor …

Study on mechanism of transdermal administration of eugenol for pain treatment by network pharmacology and molecular docking technology

H Ye, Q Lin, Q Mei, Q Liu, S Cao - Heliyon, 2024 - cell.com
The objective of this study was to explore the pharmacological mechanism of transdermal
administration of eugenol (EUG) for pain treatment. Firstly, network pharmacology …

Human Primary Odontoblast-like Cell Cultures—A Focused Review Regarding Cell Characterization

C Klein, C Meller, E Schäfer - Journal of Clinical Medicine, 2022 - mdpi.com
Cell cultures can provide useful in vitro models. Since odontoblasts are postmitotic cells,
they cannot be expanded in cell cultures. Due to their extension into the dentin, injuries are …

HIPERSENSIBILIDADE DENTINÁRIA: UMA REVISÃO BIBLIOGRÁFICA ACERCA DA PREVALÊNCIA, ETIOLOGIA, DIAGNÓSTICO E TRATAMENTO

R FERNANDES, ANA CAROLINE, EA PEREIRA - 2022 - dspace.uniube.br
A hipersensibilidade dentinária (HD) é um sintoma comum encontrado na prática
odontológica. Pode incomodar os pacientes durante a alimentação, beber e escovar os …