The dynamic transition between epithelial-like and mesenchymal-like cell states has been a
focus for extensive investigation for decades, reflective of the importance of Epithelial …

A wide variety of cellular function depends on the dynamics of intracellular Ca2+ signals.
Especially for relatively slow and lasting processes such as gene expression, cell …

Emerging evidences have highlighted the crucial role of microRNAs (miRNAs) in the liver
cirrhosis, but the relationship between miR-130a-3p and liver cirrhosis is not entirely clear …

Over 80% of multiple-tested siRNAs and shRNAs targeting CD95 or CD95 ligand (CD95L)
induce a form of cell death characterized by simultaneous activation of multiple cell death …

Many small-interfering (si) RNAs are toxic to cancer cells through a 6mer seed sequence
(positions 2–7 of the guide strand). Here we performed an siRNA screen with all 4096 6mer …

MicroRNAs (miRNAs) are a family of short, noncoding RNAs that can regulate gene
expression levels of over half of the human genome. Previous studies on the role of miRNAs …

Network coordinates of cellular processes (proteostasis, proteolysis, and endocytosis), and
molecular chaperones are the key complements in the cell machinery and processes …

Off-target effects (OTEs) represent a significant caveat for RNAi caused by substantial
complementarity between siRNAs and unintended mRNAs. We now discuss the existence of …

The miRNA pathway has three segments—biogenesis, targeting and downstream regulatory
effectors. We aimed to better understand their cellular control by exploring the miRNA …

Highly precise, yet flexible and responsive coordination of expression across groups of
genes underpins the integrity of many vital functions. However, our understanding of gene …