Cell‐inspired all‐aqueous microfluidics: from intracellular liquid–liquid phase separation toward advanced biomaterials

Q Ma, Y Song, W Sun, J Cao, H Yuan… - Advanced …, 2020 - Wiley Online Library
Living cells have evolved over billions of years to develop structural and functional
complexity with numerous intracellular compartments that are formed due to liquid–liquid …

Exploring the potential of all-aqueous immiscible systems for preparing complex biomaterials and cellular constructs

RC Gonçalves, MB Oliveira, JF Mano - Materials Horizons, 2024 - pubs.rsc.org
All-aqueous immiscible systems derived from liquid–liquid phase separation of incompatible
hydrophilic agents such as polymers and salts have found increasing interest in the …

Size-Optimized Layered Double Hydroxide Nanoparticles Promote Neural Progenitor Cells Differentiation of Embryonic Stem Cells Through the Regulation of M6A …

Y Bai, Y Zhu, X He, R Huang, X Xu, L Yang… - International Journal …, 2024 - Taylor & Francis
Purpose The committed differentiation fate regulation has been a difficult problem in the
fields of stem cell research, evidence showed that nanomaterials could promote the …

Neural differentiation of spheroids derived from human induced pluripotent stem cells–mesenchymal stem cells coculture

L Song, AC Tsai, X Yuan, J Bejoy, S Sart… - … Engineering Part A, 2018 - liebertpub.com
Organoids, the condensed three-dimensional (3D) tissues emerged at the early stage of
organogenesis, are a promising approach to regenerate functional and vascularized organ …

Generation of polyethylene glycol-dextran aqueous two-phase system droplets using different culture media under in vitro conditions

K Chairez-Cantu, M González-González… - Food and Bioproducts …, 2023 - Elsevier
Aqueous two-phase systems (ATPS) involve the combination of two immiscible polymers
that at certain concentrations form a biphasic separation system. Due to the physicochemical …

Characterization of polymer‐polymer aqueous two‐phase system droplets for 3D culture future applications

K Chairez‐Cantu… - Journal of Chemical …, 2023 - Wiley Online Library
BACKGROUND Cell‐based high‐throughput platforms using aqueous two‐phase systems
(ATPS) have led to the construction of 3D cultures using ATPS in which stem cells are …

Synergistic inhibition of kinase pathways overcomes resistance of colorectal cancer spheroids to cyclic targeted therapies

PS Thakuri, M Gupta, R Joshi, S Singh… - ACS pharmacology & …, 2019 - ACS Publications
Cancer cells often adapt to single-agent treatments with chemotherapeutics. Activation of
alternative survival pathways is a major mechanism of drug resistance. A potential approach …

Microprinted stem cell niches reveal compounding effect of colony size on stromal cells‐mediated neural differentiation

R Joshi, PS Thakuri, JC Buchanan, J Li… - Advanced healthcare …, 2018 - Wiley Online Library
Microenvironmental factors have a major impact on differentiation of embryonic stem cells
(ESCs). Here, a novel phenomenon that size of ESC colonies has a significant regulatory …

In vitro microscale models for embryogenesis

J Rico‐Varela, D Ho, LQ Wan - Advanced biosystems, 2018 - Wiley Online Library
Embryogenesis is a highly regulated developmental process requiring complex mechanical
and biochemical microenvironments to give rise to a fully developed and functional embryo …

Novel approach for neuronal stem cell differentiation using aqueous two‐phase systems in 3D cultures

K Chairez‐Cantu… - Journal of Chemical …, 2021 - Wiley Online Library
Stem cell therapy has emerged as a promising alternative for replacing lost cells involved in
neurodegenerative diseases. High efficiency of differentiation and full cell viability are actual …