Nitriles are ubiquitous versatile building blocks in organic synthesis. Common reactions of
nitriles include the transformation of cyano groups into carbonyl and amine moieties. The …

Nitriles are widely existed in many bioactive compounds, and they can be easily transformed
into other functional groups. Therefore, the synthesis of nitriles under cyanide-free …

The intermolecular three-component alkene vicinal dicarbofunctionalization (DCF) reaction
allows installation of two different carbon fragments. Despite extensive investigation into its …

An efficient synthesis of cyanoalkylated heteroarenes via iron-catalyzed direct C–H
cyanoalkylation of heteroarenes has been developed. Structurally diverse cyanoalkyl motifs …

The β-amino nitrile moiety and its derivatives frequently appear in natural product synthesis,
in drug design, and as ligands in asymmetric catalysis. Herein, we describe a direct route to …

A copper-catalyzed remote benzylic C–H functionalization strategy enabling 1, 2-
difunctionalization of alkenes with 2-methylbenzeneamides and nucleophiles, including …

A photoinduced, phosphoranyl radical-mediated protocol for the direct N–O cleavage of
strained cycloketone oximes via a polar/SET crossover process was developed for the first …

An efficient novel visible-light photoredox-catalyzed dual carbon–carbon bond cleavage of
methylenecyclopropanes and cycloketone oximes for the synthesis of 2 …

A photoredox approach to generate distal cyano-substituted alkyl radicals through C–C
bond cleavage of cyclobutanone oximes was developed. The radicals produced by this …

Asymmetric copper‐catalyzed intermolecular amino‐and azidocyanation reactions of
alkenes have been developed that proceed via a radical process in which a key benzylic …