Oxidative stress and 4‐hydroxy‐2‐nonenal (4‐HNE): Implications in the pathogenesis and treatment of aging‐related diseases

Y Li, T Zhao, J Li, M Xia, Y Li, X Wang… - Journal of …, 2022 - Wiley Online Library
Oxidative stress plays an important role in the development of aging‐related diseases by
accelerating the lipid peroxidation of polyunsaturated fatty acids in the cell membrane …

[HTML][HTML] The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment

H Zhang, L Fu - Acta Pharmaceutica Sinica B, 2021 - Elsevier
A major mitochondrial enzyme for protecting cells from acetaldehyde toxicity is aldehyde
dehydrogenase 2 (ALDH2). The correlation between ALDH2 dysfunction and …

Pro-oxidant enzymes, redox balance and oxidative damage to proteins, lipids and DNA in colorectal cancer tissue. Is oxidative stress dependent on tumour budding …

J Zińczuk, M Maciejczyk, K Zaręba, A Pryczynicz… - Cancers, 2020 - mdpi.com
This study is the first to assess redox homeostasis in patients with colorectal cancer (CRC) in
respect to histopathological parameters associated with the tumour microenvironment such …

Understanding the clinical use of levosimendan and perspectives on its future in oncology

E Ribeiro, N Vale - Biomolecules, 2023 - mdpi.com
Drug repurposing, also known as repositioning or reprofiling, has emerged as a promising
strategy to accelerate drug discovery and development. This approach involves identifying …

[HTML][HTML] The evaluation of oxidative stress parameters in breast and colon cancer

BP Kundaktepe, V Sozer, S Durmus, PC Kocael… - Medicine, 2021 - journals.lww.com
Our aim in this study was to investigate the relationship between serum ischemia modified
albumin (IMA) levels with oxidative stress parameters [protein carbonyl (PCO), advanced …

The role of STAT3/p53 and PI3K-Akt-mTOR signaling pathway on DEHP-induced reproductive toxicity in pubertal male rat

G Fu, J Dai, Z Li, F Chen, L Liu, L Yi, Z Teng… - Toxicology and Applied …, 2020 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP) is a known environmental endocrine disruptor
that impairs development of testis and spermatogenesis. This study aims to explore the …

Oxidative stress and radioiodine treatment of differentiated thyroid cancer

A Buczyńska, I Sidorkiewicz, M Rogucki, K Siewko… - Scientific reports, 2021 - nature.com
It is hypothesized that the oxidative stress level in thyroid cancer patients is additionally
upregulated by radioactive iodine (RAI) treatment, that may exert an important impact on …

Diabetes and colorectal cancer risk: a new look at molecular mechanisms and potential role of novel antidiabetic agents

J Vekic, A Zeljkovic, A Stefanovic, RV Giglio… - International Journal of …, 2021 - mdpi.com
Epidemiological data have demonstrated a significant association between the presence of
type 2 diabetes mellitus (T2DM) and the development of colorectal cancer (CRC). Chronic …

Could oxidative stress play a role in the development and clinical management of differentiated thyroid cancer?

M Kościuszko, A Buczyńska, AJ Krętowski… - Cancers, 2023 - mdpi.com
Simple Summary Increased oxidative stress (OS) has been implicated as a relevant risk
factor for cancer development and progression. The incidence of differentiated thyroid …

Critical review on fatty acid-based food and nutraceuticals as supporting therapy in cancer

C Ferreri, A Sansone, C Chatgilialoglu… - International journal of …, 2022 - mdpi.com
Fatty acids have an important place in both biological and nutritional contexts and, from a
clinical point of view, they have known consequences for diseases' onset and development …