Synthetic heterocyclic candidates as promising α-glucosidase inhibitors: An overview
M Dhameja, P Gupta - European journal of medicinal chemistry, 2019 - Elsevier
Abstract α-Glucosidase enzyme inhibition is an effective therapeutic decorum in the
treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …
treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …
Heterocyclic compounds as a magic bullet for diabetes mellitus: a review
U Farwa, MA Raza - RSC advances, 2022 - pubs.rsc.org
Diabetes mellitus (DM) is a major metabolic disorder due to hyperglycemia, which is
increasing all over the world. From the last two decades, the use of synthetic agents has …
increasing all over the world. From the last two decades, the use of synthetic agents has …
Design and preparation of ZnS‐ZnFe2O4: a green and efficient hybrid nanocatalyst for the multicomponent synthesis of 2,4,5‐triaryl‐1H‐imidazoles
In the present work, a new protocol was introduced for the preparation of an efficient hybrid
nanocatalyst ZnS‐ZnFe2O4 via the co‐precipitation method as well as its application in the …
nanocatalyst ZnS‐ZnFe2O4 via the co‐precipitation method as well as its application in the …
Facile synthesis of imidazoles by an efficient and eco-friendly heterogeneous catalytic system constructed of Fe3O4 and Cu2O nanoparticles, and guarana as a …
In this study, an efficient hybrid nanocatalyst made of guar gum (guarana, as a natural
basis), magnetic iron oxide nanoparticles, and copper (I) oxide nanoparticles (Cu 2 O NPs) …
basis), magnetic iron oxide nanoparticles, and copper (I) oxide nanoparticles (Cu 2 O NPs) …
Imidazo[1,2-c]quinazolines as a novel and potent scaffold of α-glucosidase inhibitors: design, synthesis, biological evaluations, and in silico studies
F Peytam, F Hosseini, M Hekmati, B Bayati… - Scientific Reports, 2023 - nature.com
Abstract α-Glucosidase inhibition is an approved treatment for type 2 diabetes mellitus
(T2DM). In an attempt to develop novel anti-α-glucosidase agents, two series of substituted …
(T2DM). In an attempt to develop novel anti-α-glucosidase agents, two series of substituted …
An insight into the medicinal perspective of synthetic analogs of imidazole
Imidazole remains a privileged heterocycle in drug discovery. Imidazole scaffold is a
ubiquitous motif that is present in several pharmacologically important drug molecules such …
ubiquitous motif that is present in several pharmacologically important drug molecules such …
Discovery of novel 4, 5-diphenyl-imidazol-α-aminophosphonate hybrids as promising anti-diabetic agents: Design, synthesis, in vitro, and in silico enzymatic studies
Herein, a novel series of 4, 5-diphenyl-imidazol-α-aminophosphonate hybrids 4a-m was
designed, synthesized, and evaluated as new anti-diabetic agents. These compounds were …
designed, synthesized, and evaluated as new anti-diabetic agents. These compounds were …
Synthesis and biological evaluation of novel 2, 4, 5-triarylimidazole–1, 2, 3-triazole derivatives via click chemistry as α-glucosidase inhibitors
G Wang, Z Peng, J Wang, J Li, X Li - Bioorganic & medicinal chemistry …, 2016 - Elsevier
Abstract A novel series of 2, 4, 5-triarylimidazole–1, 2, 3-triazole derivatives were
synthesized via copper (I)-catalyzed azide–alkyne click chemistry, and evaluated for their α …
synthesized via copper (I)-catalyzed azide–alkyne click chemistry, and evaluated for their α …
Pyridine sulfonamide as a small key organic molecule for the potential treatment of type-II diabetes mellitus and Alzheimer's disease: in vitro studies against yeast α …
This paper presents the efficient high yield synthesis of novel pyridine 2, 4, 6-
tricarbohydrazide derivatives (4a–4i) along with their α-glucosidase, acetylcholinesterase …
tricarbohydrazide derivatives (4a–4i) along with their α-glucosidase, acetylcholinesterase …
Design, synthesis, α-glucosidase inhibitory activity, molecular docking and QSAR studies of benzimidazole derivatives
L Dinparast, H Valizadeh, MB Bahadori… - Journal of Molecular …, 2016 - Elsevier
In this study the green, one-pot, solvent-free and selective synthesis of benzimidazole
derivatives is reported. The reactions were catalyzed by ZnO/MgO containing ZnO …
derivatives is reported. The reactions were catalyzed by ZnO/MgO containing ZnO …