Abstract Latent Epstein–Barr virus (EBV) infection has a substantial role in causing many
human disorders. The persistence of these viral genomes in all malignant cells, yet with the …

To make the appropriate developmental decisions or maintain homeostasis, cells and
organisms must coordinate the expression of their genome and metabolic state. However …

Monoubiquitination of histone H2B on lysine 120 (H2Bub1) is an epigenetic mark generally
associated with transcriptional activation, yet the global functions of H2Bub1 remain poorly …

The histone demethylase PHF8 has been implicated in multiple pathological disorders,
including X-linked mental retardation and tumorigenesis. However, it is not clear how the …

The post-translational attachment of one or several ubiquitin molecules to a protein
generates a variety of targeting signals that are used in many different ways in the cell …

The ubiquitin-specific protease USP7/HAUSP regulates p53 and MDM2 levels, and cellular
localization of FOXO4 and PTEN, and hence is critically important for their role in cellular …

The deubiquitylating enzyme USP7 (HAUSP) sits at a critical node regulating the activities of
numerous proteins broadly characterized as tumor suppressors, DNA repair proteins …

Ubiquitin-specific proteases (USPs) are papain-like isopeptidases with variable inter-and
intramolecular regulatory domains. To understand the effect of these domains on USP …

Deubiquitinases (DUBs) play important roles and therefore are potential drug targets in
various diseases including cancer and neurodegeneration. In this review, we recapitulate …

Degrons are the elements that are used by E3 ubiquitin ligases to target proteins for
degradation. Most degrons are short linear motifs embedded within the sequences of …