The discovery of anticancer drugs is now driven by the numerous molecular alterations
identified in tumor cells over the past decade. To exploit these alterations, it is necessary to …

HOX genes encode an evolutionarily conserved set of transcription factors that control how
the phenotype of an organism becomes organized during development based on its genetic …

NPM1 is the most frequently mutated gene in cytogenetically normal acute myeloid leukemia
(AML). In AML cells, NPM1 mutations result in abnormal cytoplasmic localization of the …

An emerging concept in the field of cancer biology is that a rare population of 'tumour stem
cells' exists among the heterogeneous group of cells that constitute a tumour. This concept …

The homeobox (HOX) genes are a highly conserved family of homeodomain-containing
transcription factors that specify cell identity in early development and, subsequently, in a …

Chromosomal translocations in the human acute leukemias rearrange the regulatory and
coding regions of a variety of transcription factor genes. The resultant protein products can …

Many cancers seem to depend on a small population of'cancer stem cells' for their continued
growth and propagation. The leukaemia stem cell (LSC) was the first such cell to be …

Abstract Hoxa9, Meis1 and Pbx1 encode homeodomaincontaining proteins implicated in
leukemic transformation in both mice and humans. Hoxa9, Meis1 and Pbx1 proteins have …

Hox transcription factors have emerged as important regulators of primitive hematopoietic
cell proliferation and differentiation. In particular, HOXB4 appears to be a strong positive …

Gene expression analyses, gene targeting experiments and retroviral overexpression
studies in the murine bone marrow transplantation model have provided strong correlative …