Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Pericytes, attached to the surface of capillaries, play an important role in regulating local
blood flow. Using optogenetic tools and genetically encoded reporters in conjunction with …

Blood flow into the brain is dynamically regulated to satisfy the changing metabolic
requirements of neurons, but how this is accomplished has remained unclear. Here we …

Endothelial cells in resistance arteries, arterioles, and capillaries express a diverse array of
ion channels that contribute to Cell-Cell communication in the microcirculation. Endothelial …

Potassium channels importantly contribute to the regulation of vascular smooth muscle
(VSM) contraction and growth. They are the dominant ion conductance of the VSM cell …

Biological tissues are fed by arterial networks whose task is to set blood flow delivery in
accordance with energetic demand. Coordinating vasomotor activity among hundreds of …

Upon stimulation with agonists and shear stress, the vascular endothelium of different
vessels selectively releases several vasodilator factors such as nitric oxide and prostacyclin …

The phosphoinositide, phosphatidylinositol 4, 5-bisphosphate (PIP2), has long been
established as a major contributor to intracellular signaling, primarily by virtue of its role as a …

Key points Endothelial inwardly rectifying K+ (Kir2. 1) channels regulate flow‐induced
vasodilatation via nitric oxide (NO) in mouse mesenteric resistance arteries. Deficiency of …

Neuronal activity leads to an increase in local cerebral blood flow (CBF) to allow adequate
supply of oxygen and nutrients to active neurons, a process termed neurovascular coupling …