Neutrophils are the most abundant immune cell type in the blood and constitute the first line
of defense against invading pathogens. Despite their important role in many diseases, they …

Understanding immunity in humans to Group A Streptococcus (Strep A) is critical for the
development of successful vaccines to prevent the morbidity and mortality attributed to Strep …

Background Streptococcus pyogenes (group A Streptococcus, Strep A) is a widespread
pathogen that continues to pose a significant threat to human health. The development of a …

Recent global advocacy efforts have highlighted the importance of development of a vaccine
against group A Streptococcus (GAS). Combo5 is a non-M protein-based vaccine that …

Abstract Development of an effective vaccine against the leading human bacterial pathogen
group A Streptococcus (GAS) is a public health priority. The species defining group A cell …

Group A Streptococcus (GAS) and GAS-related infections are a worldwide challenge, with
no commercial GAS vaccine available. Polyethylenimine (PEI) attaches to the cells' surface …

Coiled coil–forming M proteins of the widespread and potentially deadly bacterial pathogen
Streptococcus pyogenes (strep A) are immunodominant targets of opsonizing antibodies …

Abstract Background Group A Streptococcus (Strep A) causes both uncomplicated and
severe invasive infections, as well as the post-infection complications acute rheumatic fever …

The M protein of group A streptococci (Strep A) is a major virulence determinant and
protective antigen. The N-terminal region of the M protein is variable in sequence, defines …

Group A streptococcal infections are a significant cause of global morbidity and mortality. A
leading vaccine candidate is the surface M protein, a major virulence determinant and …