The blood–brain barrier (BBB) prevents efficient drug delivery to the central nervous system.
As a result, brain diseases remain one of the greatest unmet medical needs. Understanding …

During the last decades, the ever-increasing incidence of various diseases, like cancer, has
led to a high rate of death worldwide. On the other hand, conventional modalities (such as …

Although some tumor has become a curable disease for many patients, involvement of the
central nervous system (CNS) is still a major concern. The blood–brain barrier (BBB), a …

This encompassing review article synthesizes multiple studies and methods all revolving
around the innovative use of nanoparticles (NPs) for Vincristine (VCR) delivery as a cancer …

Puerarin is an isoflavone compound derived from Pueraria lobata in traditional Chinese
medicine. Accumulating evidence has indicated that puerarin demonstrates multiple …

Lung cancer is the second most prevalent and first killer cancer worldwide, and conventional
approaches do not have enough ability to suppress it. Therefore, a novel targeted chitosan …

Addressing disorders related to the central nervous system (CNS) remains a complex
challenge because of the presence of the blood-brain barrier (BBB), which restricts the entry …

The present study investigates the brain-targeted efficiency of atomoxetine (AXT)-loaded
nanostructured lipid carrier (NLC)-laden thermosensitive in situ gel after intranasal …

Central nervous system (CNS) diseases, ranging from brain cancers to neurodegenerative
disorders like dementia and acute conditions such as strokes, have been heavily burdening …

Currently, about 40% of approved drugs and nearly 90% of drug candidates are poorly
water-soluble drugs. Low solubility reduces the likelihood that these drugs can be effectively …