Advancements to the axolotl model for regeneration and aging

WA Vieira, KM Wells, CD McCusker - Gerontology, 2020 - karger.com
Loss of regenerative capacity is a normal part of aging. However, some organisms, such as
the Mexican axolotl, retain striking regenerative capacity throughout their lives. Moreover …

The computational boundary of a “self”: developmental bioelectricity drives multicellularity and scale-free cognition

M Levin - Frontiers in psychology, 2019 - frontiersin.org
All epistemic agents physically consist of parts that must somehow comprise an integrated
cognitive self. Biological individuals consist of subunits (organs, cells, and molecular …

Scale‐free biology: Integrating evolutionary and developmental thinking

C Fields, M Levin - BioEssays, 2020 - Wiley Online Library
When the history of life on earth is viewed as a history of cell division, all of life becomes a
single cell lineage. The growth and differentiation of this lineage in reciprocal interaction …

En1 and Lmx1b do not recapitulate embryonic dorsal-ventral limb patterning functions during mouse digit tip regeneration

GL Johnson, MB Glasser, JF Charles, J Duryea… - Cell reports, 2022 - cell.com
The mouse digit tip regenerates following amputation. How the regenerate is patterned is
unknown, but a long-standing hypothesis proposes developmental patterning mechanisms …

An emerging frontier in intercellular communication: extracellular vesicles in regeneration

PN Avalos, DJ Forsthoefel - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Regeneration requires cellular proliferation, differentiation, and other processes that are
regulated by secreted cues originating from cells in the local environment. Recent studies …

The biophysics of regenerative repair suggests new perspectives on biological causation

M Levin - BioEssays, 2020 - Wiley Online Library
Evolution exploits the physics of non‐neural bioelectricity to implement anatomical
homeostasis: a process in which embryonic patterning, remodeling, and regeneration …

Integration failure of regenerated limb tissue is associated with incongruencies in positional information in the Mexican axolotl

WA Vieira, M Raymond, K Kelley… - Frontiers in Cell and …, 2023 - frontiersin.org
Introduction: Little is known about how the newly regenerated limb tissues in the Mexican
axolotl seamlessly integrate with the remaining stump tissues to form a functional structure …

Tig1 regulates proximo-distal identity during salamander limb regeneration

CR Oliveira, D Knapp, A Elewa, T Gerber… - nature …, 2022 - nature.com
Salamander limb regeneration is an accurate process which gives rise exclusively to the
missing structures, irrespective of the amputation level. This suggests that cells in the stump …

Forever young: Linking regeneration and genome size in salamanders

SK Sessions, DB Wake - Developmental Dynamics, 2021 - Wiley Online Library
Background Salamanders stand out among vertebrate animals in two key characteristics:
their ability to regenerate body parts, and their large and variable genome sizes. Results …

Making a new limb out of old cells: exploring endogenous cell reprogramming and its role during limb regeneration

MJ Raymond Jr, CD McCusker - American Journal of …, 2024 - journals.physiology.org
Cellular reprogramming is characterized by the induced dedifferentiation of mature cells into
a more plastic and potent state. This process can occur through artificial reprogramming …