Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …

CD36, a scavenger receptor expressed in multiple cell types, mediates lipid uptake,
immunological recognition, inflammation, molecular adhesion, and apoptosis. CD36 is a …

The biological functions of sirtuin 6 (SIRT6; eg, deacetylation, defatty‐acylation, and mono‐
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …

CD36 (also known as scavenger receptor B2) is a multifunctional receptor that mediates the
binding and cellular uptake of long-chain fatty acids, oxidized lipids and phospholipids …

Autophagy is a highly orchestrated intracellular bulk degradation process that is activated by
various environmental stresses. The serine/threonine kinase ULK1, like its yeast homologue …

Apoptosis induced by p53 is firmly established as a central mechanism of tumour
suppression. In addition to its complex functions as a nuclear transcription factor, p53 can …

Cardiomyocyte inflammation followed by apoptosis and fibrosis is an important mediator for
development and progression of heart failure. Activation of toll-like receptor 4 (TLR4), an …

In this study, We demonstrated that Bax mitochondrial translocation plays a vital role in the
initiation of the mitochondrial signaling pathway upon activation by heat stress. In addition …

Understanding axon regenerative failure remains a major goal in neuroscience, and
reversing this failure remains a major goal for clinical neurology. Although an inhibitory …

Cells apoptosis induced by intense heat stress is the prominent feature of heat-related
illness. However, little is known about the biological effects of heat stress on cells apoptosis …