The propagation of all organisms depends on the accurate and orderly segregation of
chromosomes in mitosis and meiosis. Budding yeast has long served as an outstanding …

Successful completion of mitosis requires that sister kinetochores become attached end-on
to the plus ends of spindle microtubules (MTs) in prometaphase, thereby forming …

Background In the intracellular environment, motor-driven cargo must navigate a dense
cytoskeletal network among abundant organelles. Results We investigated the effects of the …

Successful mitosis depends on the stable, yet regulated attachment of chromosomes to
spindle microtubules. The kinetochore, a large macromolecular structure assembled at sites …

The development of cryo-electron microscopy (cryo-EM) allowed microtubules to be
captured in their solution-like state, enabling decades of insight into their dynamic …

The mechanisms by which sister chromatids maintain biorientation on the metaphase
spindle are critical to the fidelity of chromosome segregation. Active force interplay exists …

The main physiological function of mitotic kinetochores is to provide durable attachment to
spindle microtubules, which segregate chromosomes in order to partition them equally …

The human body is a composite of diverse materials able to perform specific functions. Few
of these materials are simple liquids or solids; rather they share both liquid-like and solid …

In mitosis, faithful chromosome segregation is orchestrated by the dynamic interactions
between the spindle microtubules (MTs) emanating from the opposite poles and the …

The faithful segregation of duplicated sister chromatids rely on the remarkable ability of
kinetochores to sustain stable load bearing attachments with the dynamic plus ends of …