INTRODUCTION Protein-protein interactions play critical roles in biology, but the structures
of many eukaryotic protein complexes are unknown, and there are likely many interactions …

The functions of coat protein complex II (COPII) coats in cargo packaging and the creation of
vesicles at the endoplasmic reticulum are conserved in eukaryotic protein secretion …

The realization that the meticulous organization of cellular organelles is not required for the
reconstitution of select intracellular traffic steps has revolutionized cell biology. It transformed …

Retromer is a master regulator of cargo retrieval from endosomes, which is critical for many
cellular processes including signaling, immunity, neuroprotection, and virus infection. The …

The fidelity of protein transport in the secretory pathway relies on the accurate sorting of
proteins to their correct destinations. To deepen our understanding of the underlying …

Intrinsically disordered regions (IDRs) are structurally flexible protein segments with
regulatory functions in multiple contexts, such as in the assembly of biomolecular …

COPII mediates Endoplasmic Reticulum to Golgi trafficking of thousands of cargoes. Five
essential proteins assemble into a two-layer architecture, with the inner layer thought to …

APOB-containing lipoproteins are large, complex lipid carriers that ferry bulk lipids into the
circulation via the secretory pathway, originating from the endoplasmic reticulum of …

The endoplasmic reticulum (ER) is the main harbor for newly synthesized proteins in
eukaryotic cells. Through a continuous membrane network of sheets and tubules, the ER …

Autophagy–a highly regulated intracellular degradation process–is pivotal in maintaining
cellular homeostasis. Liquid–liquid phase separation (LLPS) is a fundamental mechanism …