The T-box family of transcription factors exhibits widespread involvement throughout
development in all metazoans. T-box proteins are characterized by a DNA-binding motif …

The cardiac conduction system (CCS) consists of distinctive components that initiate and
conduct the electrical impulse required for the coordinated contraction of the cardiac …

MAPK signaling inhibitor (MAPKi) therapies show limited efficacy for advanced thyroid
cancers despite constitutive activation of the signaling correlates with disease recurrence …

The mammalian heart is the first functional organ, the first indicator of life. Its normal
formation and function are essential for fetal life. Defects in heart formation lead to …

Over the last decade, mouse models have become a popular instrument for studying cardiac
arrhythmias. This review assesses in which respects a mouse heart is a miniature human …

In the mammalian heart a conduction system of nodes and conducting cells generates and
transduces the electrical signals evoking myocardial contractions. Specialized pacemaker …

The contraction pattern of the heart relies on the activation and conduction of the electrical
impulse. Perturbations of cardiac conduction have been associated with congenital and …

The rate and rhythm of heart muscle contractions are coordinated by the cardiac conduction
system (CCS), a generic term for a collection of different specialized muscular tissues within …

Aim Treatment of disorders of the sinus node or the atrioventricular node requires insights
into the molecular mechanisms of development and homoeostasis of these pacemaker …

Cardiac conduction system (CCS) disease, which results in disrupted conduction and
impaired cardiac rhythm, is common with significant morbidity and mortality. Current …