Immune cells and glia interact with neurons to alter pain sensitivity and to mediate the
transition from acute to chronic pain. In response to injury, resident immune cells are …

Neprilysin has a major role in both the generation and degradation of bioactive peptides.
LCZ696 (valsartan/sacubitril, Entresto), the first of the new ARNI (dual-acting angiotensin …

Objective The objective of this study was to identify new causes of Charcot–Marie–Tooth
(CMT) disease in patients with autosomal‐recessive (AR) CMT. Methods To efficiently …

Abstract Background Acorus calamus (family: Araceae), is an indigenous plant, traditionally
it is used as an ingredient of various cocktail preparations and for the management of severe …

Abstract Complex Regional Pain Syndrome (CRPS) is an excess and/or prolonged pain and
inflammation condition that follows an injury to a limb. The pathogenesis of CRPS is …

The amyloid cascade hypothesis of Alzheimer′ s disease (AD) postulates that
accumulation in the brain of amyloid β‐peptide (Aβ) is the primary trigger for neuronal loss …

Bradykinin has important physiological actions related to the regulation of blood vessel tone
and renal function, and protection from ischemia reperfusion injury. However, bradykinin …

The spinal dorsal horn (SDH) is comprised of distinct neuronal populations that process
different somatosensory modalities. Somatostatin (SST)-expressing interneurons in the SDH …

The endogenous opioid and cannabinoid systems are involved in the physiological
inhibitory control of pain and are of particular interest for the development of therapeutic …

Axonal polyneuropathies are a frequent cause of progressive disability in the elderly.
Common etiologies comprise diabetes mellitus, paraproteinaemia, and inflammatory …