Cancers are not composed merely of cancer cells alone; instead, they are complex
'ecosystems' comprising many different cell types and noncellular factors. The tumour stroma …

Clinical evidence demonstrates that treatment with immune checkpoint inhibitor
immunotherapy agents can have considerable benefit across multiple tumours. However …

There has been an exponential growth in the performance and output of sequencing
technologies (omics data) with full genome sequencing now producing gigabases of reads …

Cancer is a genetic disease where genetic variations cause abnormally functioning genes
that appear to alter expression. Proteins, the final products of gene expression, determine …

In this study, three (3) neural networks (NN) were designed to discriminate between
malignant (n= 78) and benign (n= 88) breast tumors using their respective attenuated total …

Molecular profiling from liquid biopsy, in particular cell-free DNA (cfDNA), represents an
attractive alternative to tissue biopsies for the detection of actionable targets and tumor …

Anticancer target drugs (ATDs) specifically bind and inhibit molecular targets that play
important roles in cancer development and progression, being deeply implicated in …

Background Analysis of circulating tumor nucleic acids in plasma of Non-Small Cell Lung
Cancer (NSCLC) patients is the most widespread and documented form of" liquid biopsy" …

Mechanistically, chimeric genes result from DNA rearrangements and include parts of
preexisting normal genes combined at the genomic junction site. Some rearranged genes …

Intracellular molecular pathways (IMPs) control all major events in the living cell. IMPs are
considered hotspots in biomedical sciences and thousands of IMPs have been discovered …