The clinical success of cancer immune checkpoint blockade (ICB) has refocused attention
on tumor-infiltrating lymphocytes (TILs) across cancer types. The outcome of immune …

Following antigen encounter and subsequent resolution of the immune response, a single
naïve T cell is able to generate multiple subsets of memory T cells with different phenotypic …

Chemotherapy combined with immunotherapy has improved the treatment of certain solid
tumors, but effective regimens remain elusive for pancreatic ductal adenocarcinoma …

SARS-CoV-2 spike mRNA vaccines,–mediate protection from severe disease as early as ten
days after prime vaccination, when neutralizing antibodies are hardly detectable,–. Vaccine …

SARS-CoV-2 mRNA vaccines have shown remarkable clinical efficacy, but questions
remain about the nature and kinetics of T cell priming. We performed longitudinal antigen …

T cells are the major arm of the immune system responsible for controlling and regressing
cancers. To identify genes limiting T cell function, we conducted genome-wide CRISPR …

Naive T cells have long been regarded as a developmentally synchronized and fairly
homogeneous and quiescent cell population, the size of which depends on age, thymic …

In metazoans, specific tasks are relegated to dedicated organs that are established early in
development, occupy discrete locations and typically remain fixed in size. The adult immune …

Understanding immune responses to SARS-CoV-2 messenger RNA (mRNA) vaccines is of
great interest, principally because of the poor knowledge about the mechanisms of …

Despite being a standard treatment option in breast cancer, immune checkpoint inhibitors
(ICIs) are only efficacious for a subset of patients. To gain a better understanding of the …