Small guanosine triphosphatases (GTPases) of the Ras superfamily are key regulators of
many key cellular events such as proliferation, differentiation, cell cycle regulation …

The progress we have made in understanding Alzheimer's disease (AD) pathogenesis has
led to the identification of several novel pathways and potential therapeutic targets. Rho …

Aptamer-based proteomics revealed differentially abundant proteins in Alzheimer's disease
(AD) brains in the Baltimore Longitudinal Study of Aging and Religious Orders Study (mean …

Background Identifying novel therapeutic targets is crucial for the successful development of
drugs. However, the cost to experimentally identify therapeutic targets is huge and only …

Amyloid beta (Aβ)-mediated synapse dysfunction is an early event in Alzheimer's disease
(AD) pathogenesis and previous studies suggest that NMDA receptor (NMDAR) …

Olfactory dysfunction is among the earliest features of Alzheimer's disease (AD). Although
neuropathological abnormalities have been detected in the olfactory bulb (OB), little is …

Abstract The small RhoGTPase Rac1 is implicated in a variety of events related to actin
cytoskeleton rearrangement. Remarkably, another event that is completely different from …

Ischemic stroke and Alzheimer's disease (AD), despite being distinct disease entities, share
numerous pathophysiological mechanisms such as those mediated by inflammation …

Innovative therapeutic strategies are urgently needed for Alzheimer's disease (AD) due to
the increasing size of the aging population and the lack of effective drug treatment. Here, we …

Early-onset Alzheimer disease (AD)-like pathology in Down syndrome is commonly
attributed to an increased dosage of the amyloid precursor protein (APP) gene. To test this in …