Encouraging an excitable brain state: mechanisms of brain repair in stroke

MT Joy, ST Carmichael - Nature Reviews Neuroscience, 2021 - nature.com
Stroke induces a plastic state in the brain. This period of enhanced plasticity leads to the
sprouting of new axons, the formation of new synapses and the remapping of sensory-motor …

Is it possible to overcome issues of external validity in preclinical animal research? Why most animal models are bound to fail

P Pound, M Ritskes-Hoitinga - Journal of translational medicine, 2018 - Springer
Background The pharmaceutical industry is in the midst of a productivity crisis and rates of
translation from bench to bedside are dismal. Patients are being let down by the current …

Agreed definitions and a shared vision for new standards in stroke recovery research: the stroke recovery and rehabilitation roundtable taskforce

J Bernhardt, KS Hayward, G Kwakkel… - … Journal of Stroke, 2017 - journals.sagepub.com
The first Stroke Recovery and Rehabilitation Roundtable established a game changing set
of new standards for stroke recovery research. Common language and definitions were …

Neuroinflammation as a key driver of secondary neurodegeneration following stroke?

SM Stuckey, LK Ong, LE Collins-Praino… - International Journal of …, 2021 - mdpi.com
Ischaemic stroke involves the rapid onset of focal neurological dysfunction, most commonly
due to an arterial blockage in a specific region of the brain. Stroke is a leading cause of …

Therapeutic potential of neurotrophins for repair after brain injury: a helping hand from biomaterials

J Houlton, N Abumaria, SFR Hinkley… - Frontiers in …, 2019 - frontiersin.org
Stroke remains the leading cause of long-term disability with limited options available to aid
in recovery. Significant effort has been made to try and minimize neuronal damage following …

Is environmental enrichment ready for clinical application in human post-stroke rehabilitation?

MW McDonald, KS Hayward… - Frontiers in behavioral …, 2018 - frontiersin.org
Environmental enrichment (EE) has been widely used as a means to enhance brain
plasticity mechanisms (eg, increased dendritic branching, synaptogenesis, etc.) and improve …

Cognition in stroke rehabilitation and recovery research: Consensus-based core recommendations from the second Stroke Recovery and Rehabilitation Roundtable

MW McDonald, SE Black, DA Copland… - … Journal of Stroke, 2019 - journals.sagepub.com
Cognitive impairment is an important target for rehabilitation as it is common following
stroke, is associated with reduced quality of life and interferes with motor and other types of …

A translational roadmap for transcranial magnetic and direct current stimulation in stroke rehabilitation: Consensus-based core recommendations from the third stroke …

JD Edwards, AU Dominguez-Vargas… - … Journal of Stroke, 2024 - journals.sagepub.com
Background and Aims: The purpose of this Third Stroke Recovery and Rehabilitation
Roundtable (SRRR3) was to develop consensus recommendations to address outstanding …

Advanced neurotechnologies for the restoration of motor function

S Micera, M Caleo, C Chisari, FC Hummel, A Pedrocchi - Neuron, 2020 - cell.com
Stroke is one of the leading causes of long-term disability. Advanced technological solutions
(" neurotechnologies") exploiting robotic systems and electrodes that stimulate the nervous …

A stroke recovery trial development framework: consensus-based core recommendations from the second stroke recovery and rehabilitation roundtable

J Bernhardt, KS Hayward, N Dancause… - … Journal of Stroke, 2019 - journals.sagepub.com
A major goal of the Stroke Recovery and Rehabilitation Roundtable (SRRR) is to accelerate
development of effective treatments to enhance stroke recovery beyond that expected to …