Importance of Inherent Substrate Reactivity in Enzyme‐Promoted Carbocation Cyclization/Rearrangements
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Abstract β-Elemene is a valuable sesquiterpene isolated from the essential oil of the
traditional Chinese medicine Curcuma wenyujin. As a Chinese class II non-cytotoxic …

Engineering sesquiterpene synthases to form predefined alternative products is a major
challenge due to their diversity in cyclization mechanisms and our limited understanding of …

Abstract β‐elemene is one of the most commonly used antineoplastic drugs in cancer
treatment. As a plant‐derived natural chemical, biologically engineering microorganisms to …

The substrate flexibility of eight purified sesquiterpene cyclases was evaluated using six
new heteroatom‐modified farnesyl pyrophosphates, and the formation of six new …

Artemisinin from the plant Artemisia annua is the most potent pharmaceutical for the
treatment of malaria. In the plant, the sesquiterpene cyclase amorphadiene synthase, a …

Natural sesquiterpene synthases have evolved to make complex terpenoids by quenching
reactive carbocations either by proton transfer or by hydroxylation (water capture) …

New sesquiterpene backbones are accessible after biotransformation of presilphiperfolan-
8β-ol synthase (BcBOT2), a fungal sesquiterpene synthase, with non-natural …

In this perspective, we highlight recent examples and trends in metabolic engineering and
synthetic biology that demonstrate the synthetic potential of enzyme and pathway …

Abstract Amorpha-4, 11-diene synthase (ADS) cyclizes the substrate farnesyl
pyrophosphate to produce amorpha-4, 11-diene as a major product. This is considered the …